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A novel combinatorial cancer immunotherapy: poly-IC and blockade of the PD-1/PD-L1 pathway
A non-antigen specific immunotherapy consisting of repeated co-administration of poly-IC and blocking antibodies targeting the programmed cell death-1 (PD-1) pathway dramatically inhibits tumor development in several mouse models of cancer. Tumor-reactive CD8(+) T cells mediate the antitumor effects...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063146/ https://www.ncbi.nlm.nih.gov/pubmed/25050210 http://dx.doi.org/10.4161/onci.28440 |