Tumor vascularity in ovarian cancer: T cells need breathing room

Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognost...

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Detalles Bibliográficos
Autores principales: Neilson, David, MacPherson, Sarah, Townsend, Katelin N, Lum, Julian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063148/
https://www.ncbi.nlm.nih.gov/pubmed/25050200
http://dx.doi.org/10.4161/onci.28272
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author Neilson, David
MacPherson, Sarah
Townsend, Katelin N
Lum, Julian J
author_facet Neilson, David
MacPherson, Sarah
Townsend, Katelin N
Lum, Julian J
author_sort Neilson, David
collection PubMed
description Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognostic for improved disease-specific survival in ovarian cancer. Thus, new immunotherapies should consider how hypoxia impacts antitumor immunity.
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spelling pubmed-40631482015-04-08 Tumor vascularity in ovarian cancer: T cells need breathing room Neilson, David MacPherson, Sarah Townsend, Katelin N Lum, Julian J Oncoimmunology Author's View Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognostic for improved disease-specific survival in ovarian cancer. Thus, new immunotherapies should consider how hypoxia impacts antitumor immunity. Landes Bioscience 2014-04-08 /pmc/articles/PMC4063148/ /pubmed/25050200 http://dx.doi.org/10.4161/onci.28272 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Neilson, David
MacPherson, Sarah
Townsend, Katelin N
Lum, Julian J
Tumor vascularity in ovarian cancer: T cells need breathing room
title Tumor vascularity in ovarian cancer: T cells need breathing room
title_full Tumor vascularity in ovarian cancer: T cells need breathing room
title_fullStr Tumor vascularity in ovarian cancer: T cells need breathing room
title_full_unstemmed Tumor vascularity in ovarian cancer: T cells need breathing room
title_short Tumor vascularity in ovarian cancer: T cells need breathing room
title_sort tumor vascularity in ovarian cancer: t cells need breathing room
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063148/
https://www.ncbi.nlm.nih.gov/pubmed/25050200
http://dx.doi.org/10.4161/onci.28272
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AT lumjulianj tumorvascularityinovariancancertcellsneedbreathingroom

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