The role of CUX1 in antagonizing NF-κB signaling in TAMs

Macrophages represent a major component of the tumor microenvironment and contribute to neoplasia initiation and cancer progression. However, the molecular mechanisms underlying these phenomena are only partially understood. Manipulating the transcriptional activity of the macrophage functional spec...

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Detalles Bibliográficos
Autores principales: Kühnemuth, Benjamin, Michl, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063149/
https://www.ncbi.nlm.nih.gov/pubmed/25050198
http://dx.doi.org/10.4161/onci.28270
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author Kühnemuth, Benjamin
Michl, Patrick
author_facet Kühnemuth, Benjamin
Michl, Patrick
author_sort Kühnemuth, Benjamin
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description Macrophages represent a major component of the tumor microenvironment and contribute to neoplasia initiation and cancer progression. However, the molecular mechanisms underlying these phenomena are only partially understood. Manipulating the transcriptional activity of the macrophage functional specification factor NF-κB by virtue of a novel regulatory factor cut-like homeobox 1 (CUX1) may provide a potential target for therapeutic intervention.
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spelling pubmed-40631492015-03-27 The role of CUX1 in antagonizing NF-κB signaling in TAMs Kühnemuth, Benjamin Michl, Patrick Oncoimmunology Author's View Macrophages represent a major component of the tumor microenvironment and contribute to neoplasia initiation and cancer progression. However, the molecular mechanisms underlying these phenomena are only partially understood. Manipulating the transcriptional activity of the macrophage functional specification factor NF-κB by virtue of a novel regulatory factor cut-like homeobox 1 (CUX1) may provide a potential target for therapeutic intervention. Landes Bioscience 2014-03-27 /pmc/articles/PMC4063149/ /pubmed/25050198 http://dx.doi.org/10.4161/onci.28270 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kühnemuth, Benjamin
Michl, Patrick
The role of CUX1 in antagonizing NF-κB signaling in TAMs
title The role of CUX1 in antagonizing NF-κB signaling in TAMs
title_full The role of CUX1 in antagonizing NF-κB signaling in TAMs
title_fullStr The role of CUX1 in antagonizing NF-κB signaling in TAMs
title_full_unstemmed The role of CUX1 in antagonizing NF-κB signaling in TAMs
title_short The role of CUX1 in antagonizing NF-κB signaling in TAMs
title_sort role of cux1 in antagonizing nf-κb signaling in tams
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063149/
https://www.ncbi.nlm.nih.gov/pubmed/25050198
http://dx.doi.org/10.4161/onci.28270
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