Discovering cancer immunotherapy targets in vivo

A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA lib...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Penghui, Wucherpfennig, Kai W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063151/
https://www.ncbi.nlm.nih.gov/pubmed/25050218
http://dx.doi.org/10.4161/onci.28500
_version_ 1782321756257648640
author Zhou, Penghui
Wucherpfennig, Kai W
author_facet Zhou, Penghui
Wucherpfennig, Kai W
author_sort Zhou, Penghui
collection PubMed
description A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.
format Online
Article
Text
id pubmed-4063151
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-40631512014-07-21 Discovering cancer immunotherapy targets in vivo Zhou, Penghui Wucherpfennig, Kai W Oncoimmunology Author's View A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics. Landes Bioscience 2014-04-17 /pmc/articles/PMC4063151/ /pubmed/25050218 http://dx.doi.org/10.4161/onci.28500 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Zhou, Penghui
Wucherpfennig, Kai W
Discovering cancer immunotherapy targets in vivo
title Discovering cancer immunotherapy targets in vivo
title_full Discovering cancer immunotherapy targets in vivo
title_fullStr Discovering cancer immunotherapy targets in vivo
title_full_unstemmed Discovering cancer immunotherapy targets in vivo
title_short Discovering cancer immunotherapy targets in vivo
title_sort discovering cancer immunotherapy targets in vivo
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063151/
https://www.ncbi.nlm.nih.gov/pubmed/25050218
http://dx.doi.org/10.4161/onci.28500
work_keys_str_mv AT zhoupenghui discoveringcancerimmunotherapytargetsinvivo
AT wucherpfennigkaiw discoveringcancerimmunotherapytargetsinvivo

Ejemplares similares