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Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer
The expansion of cancer-induced myeloid cells is thought to be one of the main obstacles to successful immunotherapy. Nevertheless, in murine tumors undergoing immune-mediated destruction by adoptively transferred T cells, we have recently shown that such cells maintain their immunosuppressive prope...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063155/ https://www.ncbi.nlm.nih.gov/pubmed/25050213 http://dx.doi.org/10.4161/onci.28464 |
| _version_ | 1782321757189832704 |
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| author | Arina, Ainhoa |
| author_facet | Arina, Ainhoa |
| author_sort | Arina, Ainhoa |
| collection | PubMed |
| description | The expansion of cancer-induced myeloid cells is thought to be one of the main obstacles to successful immunotherapy. Nevertheless, in murine tumors undergoing immune-mediated destruction by adoptively transferred T cells, we have recently shown that such cells maintain their immunosuppressive properties. Therefore, adoptive T-cell therapy can, under certain conditions, overcome myeloid cell immunosuppression. |
| format | Online Article Text |
| id | pubmed-4063155 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40631552015-04-15 Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer Arina, Ainhoa Oncoimmunology Author's View The expansion of cancer-induced myeloid cells is thought to be one of the main obstacles to successful immunotherapy. Nevertheless, in murine tumors undergoing immune-mediated destruction by adoptively transferred T cells, we have recently shown that such cells maintain their immunosuppressive properties. Therefore, adoptive T-cell therapy can, under certain conditions, overcome myeloid cell immunosuppression. Landes Bioscience 2014-04-15 /pmc/articles/PMC4063155/ /pubmed/25050213 http://dx.doi.org/10.4161/onci.28464 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Arina, Ainhoa Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer |
| title | Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer |
| title_full | Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer |
| title_fullStr | Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer |
| title_full_unstemmed | Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer |
| title_short | Rethinking the role of myeloid-derived suppressor cells in adoptive T-cell therapy for cancer |
| title_sort | rethinking the role of myeloid-derived suppressor cells in adoptive t-cell therapy for cancer |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063155/ https://www.ncbi.nlm.nih.gov/pubmed/25050213 http://dx.doi.org/10.4161/onci.28464 |
| work_keys_str_mv | AT arinaainhoa rethinkingtheroleofmyeloidderivedsuppressorcellsinadoptivetcelltherapyforcancer |