Natural killer T cell strategies to combat Epstein–Barr virus infection

Epstein–Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune recognition by natural killer T (NKT) cells. Using pharmacologic means to boost CD1d expression, potent NKT cell effector functions can be elicite...

Descripción completa

Detalles Bibliográficos
Autores principales: Priatel, John J, Chung, Brian K, Tsai, Kevin, Tan, Rusung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063158/
https://www.ncbi.nlm.nih.gov/pubmed/25050206
http://dx.doi.org/10.4161/onci.28329
_version_ 1782321757864067072
author Priatel, John J
Chung, Brian K
Tsai, Kevin
Tan, Rusung
author_facet Priatel, John J
Chung, Brian K
Tsai, Kevin
Tan, Rusung
author_sort Priatel, John J
collection PubMed
description Epstein–Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune recognition by natural killer T (NKT) cells. Using pharmacologic means to boost CD1d expression, potent NKT cell effector functions can be elicited toward EBV-infected B cells, suggesting the promise of novel strategies to target EBV-associated diseases such as some B-cell malignancies.
format Online
Article
Text
id pubmed-4063158
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-40631582015-04-09 Natural killer T cell strategies to combat Epstein–Barr virus infection Priatel, John J Chung, Brian K Tsai, Kevin Tan, Rusung Oncoimmunology Author's View Epstein–Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune recognition by natural killer T (NKT) cells. Using pharmacologic means to boost CD1d expression, potent NKT cell effector functions can be elicited toward EBV-infected B cells, suggesting the promise of novel strategies to target EBV-associated diseases such as some B-cell malignancies. Landes Bioscience 2014-04-09 /pmc/articles/PMC4063158/ /pubmed/25050206 http://dx.doi.org/10.4161/onci.28329 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Priatel, John J
Chung, Brian K
Tsai, Kevin
Tan, Rusung
Natural killer T cell strategies to combat Epstein–Barr virus infection
title Natural killer T cell strategies to combat Epstein–Barr virus infection
title_full Natural killer T cell strategies to combat Epstein–Barr virus infection
title_fullStr Natural killer T cell strategies to combat Epstein–Barr virus infection
title_full_unstemmed Natural killer T cell strategies to combat Epstein–Barr virus infection
title_short Natural killer T cell strategies to combat Epstein–Barr virus infection
title_sort natural killer t cell strategies to combat epstein–barr virus infection
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063158/
https://www.ncbi.nlm.nih.gov/pubmed/25050206
http://dx.doi.org/10.4161/onci.28329
work_keys_str_mv AT priateljohnj naturalkillertcellstrategiestocombatepsteinbarrvirusinfection
AT chungbriank naturalkillertcellstrategiestocombatepsteinbarrvirusinfection
AT tsaikevin naturalkillertcellstrategiestocombatepsteinbarrvirusinfection
AT tanrusung naturalkillertcellstrategiestocombatepsteinbarrvirusinfection

Ejemplares similares