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Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations

[Image: see text] The role of fast protein dynamics in enzyme catalysis has been of great interest in the past decade. Recent “heavy enzyme” studies demonstrate that protein mass-modulated vibrations are linked to the energy barrier for the chemical step of catalyzed reactions. However, the role of...

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Detalles Bibliográficos
Autores principales:	Wang, Zhen, Singh, Priyanka, Czekster, Clarissa M., Kohen, Amnon, Schramm, Vern L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063187/ https://www.ncbi.nlm.nih.gov/pubmed/24820793 http://dx.doi.org/10.1021/ja501936d

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