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First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report

INTRODUCTION: Enteroviruses commonly encounter babies and children and infections present in a wide variety of symptoms ranging from asymptomatic infection, benign illness, and aseptic meningitis, hand-foot-and-mouth disease to severe life-threatening disease. Some newborns develop severe disease in...

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Autores principales: Ronellenfitsch, Sebastian, Tabatabai, Julia, Böttcher, Sindy, Diedrich, Sabine, Frommhold, David, Schubert-Bast, Susanne, Poeschl, Johannes, Schnitzler, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063248/
https://www.ncbi.nlm.nih.gov/pubmed/24885145
http://dx.doi.org/10.1186/1752-1947-8-164
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author Ronellenfitsch, Sebastian
Tabatabai, Julia
Böttcher, Sindy
Diedrich, Sabine
Frommhold, David
Schubert-Bast, Susanne
Poeschl, Johannes
Schnitzler, Paul
author_facet Ronellenfitsch, Sebastian
Tabatabai, Julia
Böttcher, Sindy
Diedrich, Sabine
Frommhold, David
Schubert-Bast, Susanne
Poeschl, Johannes
Schnitzler, Paul
author_sort Ronellenfitsch, Sebastian
collection PubMed
description INTRODUCTION: Enteroviruses commonly encounter babies and children and infections present in a wide variety of symptoms ranging from asymptomatic infection, benign illness, and aseptic meningitis, hand-foot-and-mouth disease to severe life-threatening disease. Some newborns develop severe disease in the first 2 weeks of life and long-term sequelae may occur among survivors. CASE PRESENTATION: We present a case report of a Caucasian newborn baby boy with severe encephalitis and systemic coxsackievirus B3 infection. The coincidence of maternal infection as well as previous mild respiratory illness in his sister suggests either prenatal or horizontal postnatal transmission. An electroencephalogram showed a severe pathologic pattern with theta-delta-rhythm and spike-wave complexes on both hemispheres. We also observed an unusual prolonged viremia for a period of 6 weeks. Due to the lack of specific antiviral treatment options, the supportive management included ventilation and medical treatment of seizures. Phylogenetic analysis revealed a genogroup D2 virus previously exclusively detected in China and now described in Europe for the first time. CONCLUSIONS: Enteroviral infection is an important differential diagnosis in neonatal encephalitis. Prolonged viremia must be taken into account and might correlate with disease severity. The newly observed enterovirus genotype D2 is spreading from Asia to other continents.
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spelling pubmed-40632482014-06-20 First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report Ronellenfitsch, Sebastian Tabatabai, Julia Böttcher, Sindy Diedrich, Sabine Frommhold, David Schubert-Bast, Susanne Poeschl, Johannes Schnitzler, Paul J Med Case Rep Case Report INTRODUCTION: Enteroviruses commonly encounter babies and children and infections present in a wide variety of symptoms ranging from asymptomatic infection, benign illness, and aseptic meningitis, hand-foot-and-mouth disease to severe life-threatening disease. Some newborns develop severe disease in the first 2 weeks of life and long-term sequelae may occur among survivors. CASE PRESENTATION: We present a case report of a Caucasian newborn baby boy with severe encephalitis and systemic coxsackievirus B3 infection. The coincidence of maternal infection as well as previous mild respiratory illness in his sister suggests either prenatal or horizontal postnatal transmission. An electroencephalogram showed a severe pathologic pattern with theta-delta-rhythm and spike-wave complexes on both hemispheres. We also observed an unusual prolonged viremia for a period of 6 weeks. Due to the lack of specific antiviral treatment options, the supportive management included ventilation and medical treatment of seizures. Phylogenetic analysis revealed a genogroup D2 virus previously exclusively detected in China and now described in Europe for the first time. CONCLUSIONS: Enteroviral infection is an important differential diagnosis in neonatal encephalitis. Prolonged viremia must be taken into account and might correlate with disease severity. The newly observed enterovirus genotype D2 is spreading from Asia to other continents. BioMed Central 2014-05-27 /pmc/articles/PMC4063248/ /pubmed/24885145 http://dx.doi.org/10.1186/1752-1947-8-164 Text en Copyright © 2014 Ronellenfitsch et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Case Report
Ronellenfitsch, Sebastian
Tabatabai, Julia
Böttcher, Sindy
Diedrich, Sabine
Frommhold, David
Schubert-Bast, Susanne
Poeschl, Johannes
Schnitzler, Paul
First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report
title First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report
title_full First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report
title_fullStr First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report
title_full_unstemmed First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report
title_short First report of a Chinese strain of coxsackie B3 virus infection in a newborn in Germany in 2011: a case report
title_sort first report of a chinese strain of coxsackie b3 virus infection in a newborn in germany in 2011: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063248/
https://www.ncbi.nlm.nih.gov/pubmed/24885145
http://dx.doi.org/10.1186/1752-1947-8-164
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