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Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
[Image: see text] The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d(2), precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d(2), is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d(2) was increased by >30,000,000-fold (5.75...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063326/ https://www.ncbi.nlm.nih.gov/pubmed/24738968 http://dx.doi.org/10.1021/ac500952z |
Sumario: | [Image: see text] The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d(2), precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d(2), is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d(2) was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)C-phospholactate-d(2) (58 ± 4 s versus 36 ± 2 s for nondeuterated form at 47.5 mT), and large production quantities (52 μmoles in 3 mL) in aqueous medium make this compound useful as a potential contrast agent for the molecular imaging of metabolism and other applications. |
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