Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water

[Image: see text] The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d(2), precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d(2), is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d(2) was increased by >30,000,000-fold (5.75...

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Autores principales: Shchepin, Roman V., Coffey, Aaron M., Waddell, Kevin W., Chekmenev, Eduard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063326/
https://www.ncbi.nlm.nih.gov/pubmed/24738968
http://dx.doi.org/10.1021/ac500952z
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author Shchepin, Roman V.
Coffey, Aaron M.
Waddell, Kevin W.
Chekmenev, Eduard Y.
author_facet Shchepin, Roman V.
Coffey, Aaron M.
Waddell, Kevin W.
Chekmenev, Eduard Y.
author_sort Shchepin, Roman V.
collection PubMed
description [Image: see text] The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d(2), precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d(2), is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d(2) was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)C-phospholactate-d(2) (58 ± 4 s versus 36 ± 2 s for nondeuterated form at 47.5 mT), and large production quantities (52 μmoles in 3 mL) in aqueous medium make this compound useful as a potential contrast agent for the molecular imaging of metabolism and other applications.
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spelling pubmed-40633262015-04-14 Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water Shchepin, Roman V. Coffey, Aaron M. Waddell, Kevin W. Chekmenev, Eduard Y. Anal Chem [Image: see text] The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d(2), precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d(2), is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d(2) was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)C-phospholactate-d(2) (58 ± 4 s versus 36 ± 2 s for nondeuterated form at 47.5 mT), and large production quantities (52 μmoles in 3 mL) in aqueous medium make this compound useful as a potential contrast agent for the molecular imaging of metabolism and other applications. American Chemical Society 2014-04-14 2014-06-17 /pmc/articles/PMC4063326/ /pubmed/24738968 http://dx.doi.org/10.1021/ac500952z Text en Copyright © 2014 American Chemical Society Open Access on 04/14/2015
spellingShingle Shchepin, Roman V.
Coffey, Aaron M.
Waddell, Kevin W.
Chekmenev, Eduard Y.
Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
title Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
title_full Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
title_fullStr Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
title_full_unstemmed Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
title_short Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
title_sort parahydrogen induced polarization of 1-(13)c-phospholactate-d(2) for biomedical imaging with >30,000,000-fold nmr signal enhancement in water
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063326/
https://www.ncbi.nlm.nih.gov/pubmed/24738968
http://dx.doi.org/10.1021/ac500952z
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