Preventable infections in children with leukodystrophy

Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (preexisting indwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were ass...

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Detalles Bibliográficos
Autores principales: Anderson, Holly M, Wilkes, Jacob, Korgenski, Ernest Kent, Pulsipher, Michael A, Blaschke, Anne J, Hersh, Adam L, Srivastava, Rajendu, Bonkowsky, Joshua L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063358/
https://www.ncbi.nlm.nih.gov/pubmed/24955379
http://dx.doi.org/10.1002/acn3.61
Descripción
Sumario:Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (preexisting indwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection-related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio [OR] 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.

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