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Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients
BACKGROUND: Hyaluronidase (Hylase Dessau®) is a hyaluronic acid-metabolizing enzyme, which has been shown to loosen the extracellular matrix, thereby improving the diffusion of local anesthetics. Lower eyelid edema is a common post-interventional complication of cosmetic procedures performed in the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063423/ https://www.ncbi.nlm.nih.gov/pubmed/24886711 http://dx.doi.org/10.1186/2047-783X-19-30 |
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author | Hilton, Said Schrumpf, Holger Buhren, Bettina Alexandra Bölke, Edwin Gerber, Peter Arne |
author_facet | Hilton, Said Schrumpf, Holger Buhren, Bettina Alexandra Bölke, Edwin Gerber, Peter Arne |
author_sort | Hilton, Said |
collection | PubMed |
description | BACKGROUND: Hyaluronidase (Hylase Dessau®) is a hyaluronic acid-metabolizing enzyme, which has been shown to loosen the extracellular matrix, thereby improving the diffusion of local anesthetics. Lower eyelid edema is a common post-interventional complication of cosmetic procedures performed in the lid region, such as the injection of hyaluronic acid fillers for tear-trough augmentation. The purpose of this study was to validate the efficacy of hyaluronidase in the management of lower eyelid edema. METHODS: We performed a retrospective analysis with 20 patients with lower eyelid edema. Most patients (n = 14) presented with edema following hyaluronic acid injection (tear-trough augmentation), whereas the minority (n = 6) were treated due to idiopathic edema (malar edema or malar mounds). Patients were treated by local infiltration of approximately 0.2 ml to 0.5 ml of hyaluronidase (Hylase Dessau® 20 IU to 75 IU) per eyelid. Photographs were taken prior to and seven days after infiltration. RESULTS: Hyaluronidase was found to reduce effectively and rapidly or resolve eyelid edema after a single injection. No relevant adverse effects were observed. However, it must be noted that a hyaluronidase injection may also dissolve injected hyaluronic acid fillers and may therefore negatively affect tear-trough augmentations. While the effects of a treatment for edema due to tear-trough augmentation were permanent, malar edema and malar mounds reoccurred within two to three weeks. CONCLUSION: The infiltration of hyaluronidase is rapid, safe and currently the only effective option for the management of eyelid edema. No relevant adverse effects were observed. |
format | Online Article Text |
id | pubmed-4063423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40634232014-06-20 Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients Hilton, Said Schrumpf, Holger Buhren, Bettina Alexandra Bölke, Edwin Gerber, Peter Arne Eur J Med Res Research BACKGROUND: Hyaluronidase (Hylase Dessau®) is a hyaluronic acid-metabolizing enzyme, which has been shown to loosen the extracellular matrix, thereby improving the diffusion of local anesthetics. Lower eyelid edema is a common post-interventional complication of cosmetic procedures performed in the lid region, such as the injection of hyaluronic acid fillers for tear-trough augmentation. The purpose of this study was to validate the efficacy of hyaluronidase in the management of lower eyelid edema. METHODS: We performed a retrospective analysis with 20 patients with lower eyelid edema. Most patients (n = 14) presented with edema following hyaluronic acid injection (tear-trough augmentation), whereas the minority (n = 6) were treated due to idiopathic edema (malar edema or malar mounds). Patients were treated by local infiltration of approximately 0.2 ml to 0.5 ml of hyaluronidase (Hylase Dessau® 20 IU to 75 IU) per eyelid. Photographs were taken prior to and seven days after infiltration. RESULTS: Hyaluronidase was found to reduce effectively and rapidly or resolve eyelid edema after a single injection. No relevant adverse effects were observed. However, it must be noted that a hyaluronidase injection may also dissolve injected hyaluronic acid fillers and may therefore negatively affect tear-trough augmentations. While the effects of a treatment for edema due to tear-trough augmentation were permanent, malar edema and malar mounds reoccurred within two to three weeks. CONCLUSION: The infiltration of hyaluronidase is rapid, safe and currently the only effective option for the management of eyelid edema. No relevant adverse effects were observed. BioMed Central 2014-05-28 /pmc/articles/PMC4063423/ /pubmed/24886711 http://dx.doi.org/10.1186/2047-783X-19-30 Text en Copyright © 2014 Hilton et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Hilton, Said Schrumpf, Holger Buhren, Bettina Alexandra Bölke, Edwin Gerber, Peter Arne Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
title | Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
title_full | Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
title_fullStr | Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
title_full_unstemmed | Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
title_short | Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
title_sort | hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063423/ https://www.ncbi.nlm.nih.gov/pubmed/24886711 http://dx.doi.org/10.1186/2047-783X-19-30 |
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