Cargando…
Paracrine effects of stem cells in wound healing and cancer progression
Stem cells play an important role in tissue repair and cancer development. The capacity to self-renew and to differentiate to specialized cells allows tissue-specific stem cells to rebuild damaged tissue and cancer stem cells to initiate and promote cancer. Mesenchymal stem cells, attracted to wound...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063537/ https://www.ncbi.nlm.nih.gov/pubmed/24728412 http://dx.doi.org/10.3892/ijo.2014.2385 |
_version_ | 1782321806409990144 |
---|---|
author | DITTMER, JÜRGEN LEYH, BENJAMIN |
author_facet | DITTMER, JÜRGEN LEYH, BENJAMIN |
author_sort | DITTMER, JÜRGEN |
collection | PubMed |
description | Stem cells play an important role in tissue repair and cancer development. The capacity to self-renew and to differentiate to specialized cells allows tissue-specific stem cells to rebuild damaged tissue and cancer stem cells to initiate and promote cancer. Mesenchymal stem cells, attracted to wounds and cancer, facilitate wound healing and support cancer progression primarily by secreting bioactive factors. There is now growing evidence that, like mesenchymal stem cells, also tissue-specific and cancer stem cells manipulate their environment by paracrine actions. Soluble factors and microvesicles released by these stem cells have been shown to protect recipient cells from apoptosis and to stimulate neovascularization. These paracrine mechanisms may allow stem cells to orchestrate wound healing and cancer progression. Hence, understanding these stem cell-driven paracrine effects may help to improve tissue regeneration and cancer treatment. |
format | Online Article Text |
id | pubmed-4063537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-40635372014-06-23 Paracrine effects of stem cells in wound healing and cancer progression DITTMER, JÜRGEN LEYH, BENJAMIN Int J Oncol Review Stem cells play an important role in tissue repair and cancer development. The capacity to self-renew and to differentiate to specialized cells allows tissue-specific stem cells to rebuild damaged tissue and cancer stem cells to initiate and promote cancer. Mesenchymal stem cells, attracted to wounds and cancer, facilitate wound healing and support cancer progression primarily by secreting bioactive factors. There is now growing evidence that, like mesenchymal stem cells, also tissue-specific and cancer stem cells manipulate their environment by paracrine actions. Soluble factors and microvesicles released by these stem cells have been shown to protect recipient cells from apoptosis and to stimulate neovascularization. These paracrine mechanisms may allow stem cells to orchestrate wound healing and cancer progression. Hence, understanding these stem cell-driven paracrine effects may help to improve tissue regeneration and cancer treatment. D.A. Spandidos 2014-04-11 /pmc/articles/PMC4063537/ /pubmed/24728412 http://dx.doi.org/10.3892/ijo.2014.2385 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review DITTMER, JÜRGEN LEYH, BENJAMIN Paracrine effects of stem cells in wound healing and cancer progression |
title | Paracrine effects of stem cells in wound healing and cancer progression |
title_full | Paracrine effects of stem cells in wound healing and cancer progression |
title_fullStr | Paracrine effects of stem cells in wound healing and cancer progression |
title_full_unstemmed | Paracrine effects of stem cells in wound healing and cancer progression |
title_short | Paracrine effects of stem cells in wound healing and cancer progression |
title_sort | paracrine effects of stem cells in wound healing and cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063537/ https://www.ncbi.nlm.nih.gov/pubmed/24728412 http://dx.doi.org/10.3892/ijo.2014.2385 |
work_keys_str_mv | AT dittmerjurgen paracrineeffectsofstemcellsinwoundhealingandcancerprogression AT leyhbenjamin paracrineeffectsofstemcellsinwoundhealingandcancerprogression |