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Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer

A novel radiosensitization treatment involving the injection of hydrogen peroxide and sodium hyaluronate, using ultrasonic guidance, into a tumor immediately prior to intraoperative radiotherapy (IORT) was established for patients with stage IVa locally advanced unresectable pancreatic cancer. The a...

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Autores principales: NISHIOKA, AKIHITO, OGAWA, YASUHIRO, MIYATAKE, KANA, TADOKORO, MICHIKO, NOGAMI, MUNENOBU, HAMADA, NORIHIKO, KUBOTA, KEI, KARIYA, SHINNJI, KOHSAKI, TAKUHIRO, SAIBARA, TOSHIJI, OKABAYASHI, TAKEHIRO, HANAZAKI, KAZUHIRO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063561/
https://www.ncbi.nlm.nih.gov/pubmed/24959285
http://dx.doi.org/10.3892/ol.2014.2101
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author NISHIOKA, AKIHITO
OGAWA, YASUHIRO
MIYATAKE, KANA
TADOKORO, MICHIKO
NOGAMI, MUNENOBU
HAMADA, NORIHIKO
KUBOTA, KEI
KARIYA, SHINNJI
KOHSAKI, TAKUHIRO
SAIBARA, TOSHIJI
OKABAYASHI, TAKEHIRO
HANAZAKI, KAZUHIRO
author_facet NISHIOKA, AKIHITO
OGAWA, YASUHIRO
MIYATAKE, KANA
TADOKORO, MICHIKO
NOGAMI, MUNENOBU
HAMADA, NORIHIKO
KUBOTA, KEI
KARIYA, SHINNJI
KOHSAKI, TAKUHIRO
SAIBARA, TOSHIJI
OKABAYASHI, TAKEHIRO
HANAZAKI, KAZUHIRO
author_sort NISHIOKA, AKIHITO
collection PubMed
description A novel radiosensitization treatment involving the injection of hydrogen peroxide and sodium hyaluronate, using ultrasonic guidance, into a tumor immediately prior to intraoperative radiotherapy (IORT) was established for patients with stage IVa locally advanced unresectable pancreatic cancer. The aim of the present study was to assess the safety and efficacy of this novel treatment, termed Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas-IORT (KORTUC and IORT). In total, 12 patients were treated with KORTUC-IORT, external-beam radiotherapy and systemic chemotherapy using gemcitabine hydrochloride and S-1. For evaluation of the therapeutic and adverse effects, contrast-enhanced computed tomography was conducted prior to the treatment, and one and six months following KORTUC-IORT. Medical examinations were performed every month at the regularly scheduled follow-up visits. The one- and two-year survival rates were 75 and 25%, respectively, and the median survival time was 16 months. All treatments associated with KORTUC-IORT were well-tolerated by the patients, with a small number of adverse effects and no serious complications. It was identified that the delivery of KORTUC-IORT is safe and effective, in combination with external-beam radiotherapy and systemic chemotherapy, for patients with locally advanced unresectable pancreatic cancer.
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spelling pubmed-40635612014-06-23 Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer NISHIOKA, AKIHITO OGAWA, YASUHIRO MIYATAKE, KANA TADOKORO, MICHIKO NOGAMI, MUNENOBU HAMADA, NORIHIKO KUBOTA, KEI KARIYA, SHINNJI KOHSAKI, TAKUHIRO SAIBARA, TOSHIJI OKABAYASHI, TAKEHIRO HANAZAKI, KAZUHIRO Oncol Lett Articles A novel radiosensitization treatment involving the injection of hydrogen peroxide and sodium hyaluronate, using ultrasonic guidance, into a tumor immediately prior to intraoperative radiotherapy (IORT) was established for patients with stage IVa locally advanced unresectable pancreatic cancer. The aim of the present study was to assess the safety and efficacy of this novel treatment, termed Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas-IORT (KORTUC and IORT). In total, 12 patients were treated with KORTUC-IORT, external-beam radiotherapy and systemic chemotherapy using gemcitabine hydrochloride and S-1. For evaluation of the therapeutic and adverse effects, contrast-enhanced computed tomography was conducted prior to the treatment, and one and six months following KORTUC-IORT. Medical examinations were performed every month at the regularly scheduled follow-up visits. The one- and two-year survival rates were 75 and 25%, respectively, and the median survival time was 16 months. All treatments associated with KORTUC-IORT were well-tolerated by the patients, with a small number of adverse effects and no serious complications. It was identified that the delivery of KORTUC-IORT is safe and effective, in combination with external-beam radiotherapy and systemic chemotherapy, for patients with locally advanced unresectable pancreatic cancer. D.A. Spandidos 2014-07 2014-04-28 /pmc/articles/PMC4063561/ /pubmed/24959285 http://dx.doi.org/10.3892/ol.2014.2101 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
NISHIOKA, AKIHITO
OGAWA, YASUHIRO
MIYATAKE, KANA
TADOKORO, MICHIKO
NOGAMI, MUNENOBU
HAMADA, NORIHIKO
KUBOTA, KEI
KARIYA, SHINNJI
KOHSAKI, TAKUHIRO
SAIBARA, TOSHIJI
OKABAYASHI, TAKEHIRO
HANAZAKI, KAZUHIRO
Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
title Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
title_full Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
title_fullStr Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
title_full_unstemmed Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
title_short Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
title_sort safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063561/
https://www.ncbi.nlm.nih.gov/pubmed/24959285
http://dx.doi.org/10.3892/ol.2014.2101
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