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Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma

Interleukin 21 (IL-21) and its receptor, IL-21R, play a key role in innate and adaptive immunity. In the present study, the effect of IL-21 and IL-21R on the pathogenesis of diffuse large B-cell lymphoma (DLBCL) was investigated. The serum levels of IL-21 were detected by enzyme-linked immunosorbent...

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Autores principales: CHA, ZHANSHAN, GU, HAIHUI, GUO, HUIJUN, TU, XIAOHUA, ZANG, YAN, ZHAO, CHUNYAN, HUA, MEIXIAN, RECHLIC, JAMES R., OLASNOVA, LINDSAY M., SONG, HAIHAN, QIAN, BAOHUA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063596/
https://www.ncbi.nlm.nih.gov/pubmed/24959288
http://dx.doi.org/10.3892/ol.2014.2062
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author CHA, ZHANSHAN
GU, HAIHUI
GUO, HUIJUN
TU, XIAOHUA
ZANG, YAN
ZHAO, CHUNYAN
HUA, MEIXIAN
RECHLIC, JAMES R.
OLASNOVA, LINDSAY M.
SONG, HAIHAN
QIAN, BAOHUA
author_facet CHA, ZHANSHAN
GU, HAIHUI
GUO, HUIJUN
TU, XIAOHUA
ZANG, YAN
ZHAO, CHUNYAN
HUA, MEIXIAN
RECHLIC, JAMES R.
OLASNOVA, LINDSAY M.
SONG, HAIHAN
QIAN, BAOHUA
author_sort CHA, ZHANSHAN
collection PubMed
description Interleukin 21 (IL-21) and its receptor, IL-21R, play a key role in innate and adaptive immunity. In the present study, the effect of IL-21 and IL-21R on the pathogenesis of diffuse large B-cell lymphoma (DLBCL) was investigated. The serum levels of IL-21 were detected by enzyme-linked immunosorbent assay, and the expression of IL-21R on CD8(+) T cells was examined through flow cytometry. The data showed that the serum level of IL-21 was significantly decreased in the patients with DLBCL compared with the healthy controls (P<0.001), whereas the expression of IL-21R was clearly elevated on the CD8(+) T cells in the patients with DLBCL. Further analyses revealed that the downregulation of the IL-21 serum level was correlated with an increased tumor stage of DLBCL, while the expression of IL-21R on the CD8(+) T cells was positively correlated with the tumor stage. Also, the serum level of IL-21 and the proportion of IL-21R on the CD8(+) T cells were negatively correlated in the patients. Notably, it was identified that the proportion of IL-21R on the CD8(+) T cells, but not the serum level of IL-21, was significantly upregulated in the patients with bone-marrow involvement and B symptoms. These results indicate that IL-21 and IL-21R may be involved in the pathogenesis of DLBCL, in which IL-21R may reflect the progression of the disease more accurately than the serum level of IL-21.
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spelling pubmed-40635962014-06-23 Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma CHA, ZHANSHAN GU, HAIHUI GUO, HUIJUN TU, XIAOHUA ZANG, YAN ZHAO, CHUNYAN HUA, MEIXIAN RECHLIC, JAMES R. OLASNOVA, LINDSAY M. SONG, HAIHAN QIAN, BAOHUA Oncol Lett Articles Interleukin 21 (IL-21) and its receptor, IL-21R, play a key role in innate and adaptive immunity. In the present study, the effect of IL-21 and IL-21R on the pathogenesis of diffuse large B-cell lymphoma (DLBCL) was investigated. The serum levels of IL-21 were detected by enzyme-linked immunosorbent assay, and the expression of IL-21R on CD8(+) T cells was examined through flow cytometry. The data showed that the serum level of IL-21 was significantly decreased in the patients with DLBCL compared with the healthy controls (P<0.001), whereas the expression of IL-21R was clearly elevated on the CD8(+) T cells in the patients with DLBCL. Further analyses revealed that the downregulation of the IL-21 serum level was correlated with an increased tumor stage of DLBCL, while the expression of IL-21R on the CD8(+) T cells was positively correlated with the tumor stage. Also, the serum level of IL-21 and the proportion of IL-21R on the CD8(+) T cells were negatively correlated in the patients. Notably, it was identified that the proportion of IL-21R on the CD8(+) T cells, but not the serum level of IL-21, was significantly upregulated in the patients with bone-marrow involvement and B symptoms. These results indicate that IL-21 and IL-21R may be involved in the pathogenesis of DLBCL, in which IL-21R may reflect the progression of the disease more accurately than the serum level of IL-21. D.A. Spandidos 2014-07 2014-04-11 /pmc/articles/PMC4063596/ /pubmed/24959288 http://dx.doi.org/10.3892/ol.2014.2062 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
CHA, ZHANSHAN
GU, HAIHUI
GUO, HUIJUN
TU, XIAOHUA
ZANG, YAN
ZHAO, CHUNYAN
HUA, MEIXIAN
RECHLIC, JAMES R.
OLASNOVA, LINDSAY M.
SONG, HAIHAN
QIAN, BAOHUA
Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma
title Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma
title_full Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma
title_fullStr Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma
title_full_unstemmed Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma
title_short Effect of interleukin 21 and its receptor on CD8(+) T cells in the pathogenesis of diffuse large B-cell lymphoma
title_sort effect of interleukin 21 and its receptor on cd8(+) t cells in the pathogenesis of diffuse large b-cell lymphoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063596/
https://www.ncbi.nlm.nih.gov/pubmed/24959288
http://dx.doi.org/10.3892/ol.2014.2062
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