All-trans retinoic acid enhances the effect of 5-aza-2′-deoxycytidine on p16INK4a demethylation, and the two drugs synergistically activate retinoic acid receptor β gene expression in the human erythroleukemia K562 cell line

The aim of the current study was to investigate the antineoplastic activities of 5-aza-2′-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor g...

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Detalles Bibliográficos
Autores principales: XIANG, LILI, DONG, WEIMIN, WANG, RONG, WEI, JIANG, QIU, GUOQIANG, CEN, JIANNONG, CHEN, ZIXING, ZHENG, XIAO, HU, SHAOYAN, XIE, XIAOBAO, CAO, XIANGSHAN, GU, WEIYING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063607/
https://www.ncbi.nlm.nih.gov/pubmed/24959230
http://dx.doi.org/10.3892/ol.2014.2133

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