Immunological Deregulation in Classic Hodgkin Lymphoma

Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these i...

Descripción completa

Detalles Bibliográficos
Autores principales: Romano, Alessandra, Vetro, Calogero, Caocci, Giovanni, Greco, Marianna, Parrinello, Nunziatina Laura, Di Raimondo, Francesco, La Nasa, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063611/
https://www.ncbi.nlm.nih.gov/pubmed/24959336
http://dx.doi.org/10.4084/MJHID.2014.039
_version_ 1782321820754509824
author Romano, Alessandra
Vetro, Calogero
Caocci, Giovanni
Greco, Marianna
Parrinello, Nunziatina Laura
Di Raimondo, Francesco
La Nasa, Giorgio
author_facet Romano, Alessandra
Vetro, Calogero
Caocci, Giovanni
Greco, Marianna
Parrinello, Nunziatina Laura
Di Raimondo, Francesco
La Nasa, Giorgio
author_sort Romano, Alessandra
collection PubMed
description Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications.
format Online
Article
Text
id pubmed-4063611
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Università Cattolica del Sacro Cuore
record_format MEDLINE/PubMed
spelling pubmed-40636112014-06-23 Immunological Deregulation in Classic Hodgkin Lymphoma Romano, Alessandra Vetro, Calogero Caocci, Giovanni Greco, Marianna Parrinello, Nunziatina Laura Di Raimondo, Francesco La Nasa, Giorgio Mediterr J Hematol Infect Dis Review Article Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications. Università Cattolica del Sacro Cuore 2014-06-01 /pmc/articles/PMC4063611/ /pubmed/24959336 http://dx.doi.org/10.4084/MJHID.2014.039 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Romano, Alessandra
Vetro, Calogero
Caocci, Giovanni
Greco, Marianna
Parrinello, Nunziatina Laura
Di Raimondo, Francesco
La Nasa, Giorgio
Immunological Deregulation in Classic Hodgkin Lymphoma
title Immunological Deregulation in Classic Hodgkin Lymphoma
title_full Immunological Deregulation in Classic Hodgkin Lymphoma
title_fullStr Immunological Deregulation in Classic Hodgkin Lymphoma
title_full_unstemmed Immunological Deregulation in Classic Hodgkin Lymphoma
title_short Immunological Deregulation in Classic Hodgkin Lymphoma
title_sort immunological deregulation in classic hodgkin lymphoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063611/
https://www.ncbi.nlm.nih.gov/pubmed/24959336
http://dx.doi.org/10.4084/MJHID.2014.039
work_keys_str_mv AT romanoalessandra immunologicalderegulationinclassichodgkinlymphoma
AT vetrocalogero immunologicalderegulationinclassichodgkinlymphoma
AT caoccigiovanni immunologicalderegulationinclassichodgkinlymphoma
AT grecomarianna immunologicalderegulationinclassichodgkinlymphoma
AT parrinellonunziatinalaura immunologicalderegulationinclassichodgkinlymphoma
AT diraimondofrancesco immunologicalderegulationinclassichodgkinlymphoma
AT lanasagiorgio immunologicalderegulationinclassichodgkinlymphoma

Ejemplares similares