Cargando…

Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis

Angioleiomyoma is a benign soft-tissue tumor originating from vascular smooth muscle, and is rare in the head and neck. The present study retrospectively examined a cohort of patients with head and neck angioleiomyoma treated at the West China Hospital of Stomatology, and also subjected archived tis...

Descripción completa

Detalles Bibliográficos
Autores principales: LIU, YING, LI, BO, LI, LONGJIANG, LIU, YANBIN, WANG, CHENXING, ZHA, LAGABAIYILA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063654/
https://www.ncbi.nlm.nih.gov/pubmed/24959254
http://dx.doi.org/10.3892/ol.2014.2124
_version_ 1782321830558695424
author LIU, YING
LI, BO
LI, LONGJIANG
LIU, YANBIN
WANG, CHENXING
ZHA, LAGABAIYILA
author_facet LIU, YING
LI, BO
LI, LONGJIANG
LIU, YANBIN
WANG, CHENXING
ZHA, LAGABAIYILA
author_sort LIU, YING
collection PubMed
description Angioleiomyoma is a benign soft-tissue tumor originating from vascular smooth muscle, and is rare in the head and neck. The present study retrospectively examined a cohort of patients with head and neck angioleiomyoma treated at the West China Hospital of Stomatology, and also subjected archived tissues to modern immunohistochemical analysis. In total, 21 patients were treated for angioleiomyoma between 1978 and 2012 at the West China Hospital of Stomatology, Sichuan University (Chengdu, Sichuan, China). Medical records were examined and paraffin block sections were cut and stained with hematoxylin and eosin, Masson’s trichrome stain and Van Gieson stain, prior to being subjected to immunohistochemical analysis to re-evaluate and confirm the diagnoses. Angioleiomyomas were found to account for only 0.18% of the benign head and neck tumors in the patients presenting to the hospital over the past 34 years. The diagnosis was more common in males (male:female ratio, 1.625:1) and the mean age at diagnosis was 42.5 years. The most common sites were the buccal mucosa, parotid gland and palate. More than half of the tumors (61.9%) were >2 cm in diameter. Five tumors presented with pain and/or tenderness. The histological subtype was reported as solid in five cases, venous in six, cavernous in nine and venous-cavernous in one. Three tumors exhibited nerve neurofibrils. All tumors were excised with no subsequent recurrence. Cytological and imaging examinations were not useful for pre-operative diagnosis. Angioleiomyoma is a benign tumor that causes limited morbidity. Surgical excision is the only effective treatment and recurrence is rare. The present study revealed that nerves were present in a small proportion (14.3%) of tumors. It was hypothesized that the compression of nerves accompanying numerous blood vessels in the tumor may cause pain, particularly in venous- and cavernous-type angioleiomyomas.
format Online
Article
Text
id pubmed-4063654
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-40636542014-06-23 Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis LIU, YING LI, BO LI, LONGJIANG LIU, YANBIN WANG, CHENXING ZHA, LAGABAIYILA Oncol Lett Articles Angioleiomyoma is a benign soft-tissue tumor originating from vascular smooth muscle, and is rare in the head and neck. The present study retrospectively examined a cohort of patients with head and neck angioleiomyoma treated at the West China Hospital of Stomatology, and also subjected archived tissues to modern immunohistochemical analysis. In total, 21 patients were treated for angioleiomyoma between 1978 and 2012 at the West China Hospital of Stomatology, Sichuan University (Chengdu, Sichuan, China). Medical records were examined and paraffin block sections were cut and stained with hematoxylin and eosin, Masson’s trichrome stain and Van Gieson stain, prior to being subjected to immunohistochemical analysis to re-evaluate and confirm the diagnoses. Angioleiomyomas were found to account for only 0.18% of the benign head and neck tumors in the patients presenting to the hospital over the past 34 years. The diagnosis was more common in males (male:female ratio, 1.625:1) and the mean age at diagnosis was 42.5 years. The most common sites were the buccal mucosa, parotid gland and palate. More than half of the tumors (61.9%) were >2 cm in diameter. Five tumors presented with pain and/or tenderness. The histological subtype was reported as solid in five cases, venous in six, cavernous in nine and venous-cavernous in one. Three tumors exhibited nerve neurofibrils. All tumors were excised with no subsequent recurrence. Cytological and imaging examinations were not useful for pre-operative diagnosis. Angioleiomyoma is a benign tumor that causes limited morbidity. Surgical excision is the only effective treatment and recurrence is rare. The present study revealed that nerves were present in a small proportion (14.3%) of tumors. It was hypothesized that the compression of nerves accompanying numerous blood vessels in the tumor may cause pain, particularly in venous- and cavernous-type angioleiomyomas. D.A. Spandidos 2014-07 2014-05-08 /pmc/articles/PMC4063654/ /pubmed/24959254 http://dx.doi.org/10.3892/ol.2014.2124 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
LIU, YING
LI, BO
LI, LONGJIANG
LIU, YANBIN
WANG, CHENXING
ZHA, LAGABAIYILA
Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis
title Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis
title_full Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis
title_fullStr Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis
title_full_unstemmed Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis
title_short Angioleiomyomas in the head and neck: A retrospective clinical and immunohistochemical analysis
title_sort angioleiomyomas in the head and neck: a retrospective clinical and immunohistochemical analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063654/
https://www.ncbi.nlm.nih.gov/pubmed/24959254
http://dx.doi.org/10.3892/ol.2014.2124
work_keys_str_mv AT liuying angioleiomyomasintheheadandneckaretrospectiveclinicalandimmunohistochemicalanalysis
AT libo angioleiomyomasintheheadandneckaretrospectiveclinicalandimmunohistochemicalanalysis
AT lilongjiang angioleiomyomasintheheadandneckaretrospectiveclinicalandimmunohistochemicalanalysis
AT liuyanbin angioleiomyomasintheheadandneckaretrospectiveclinicalandimmunohistochemicalanalysis
AT wangchenxing angioleiomyomasintheheadandneckaretrospectiveclinicalandimmunohistochemicalanalysis
AT zhalagabaiyila angioleiomyomasintheheadandneckaretrospectiveclinicalandimmunohistochemicalanalysis