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Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations

MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-...

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Autores principales: Zhang, Junjie, Huang, Xuewen, Xiao, Juanjuan, Yang, Yajun, Zhou, Yinghui, Wang, Xiaofeng, Liu, Qingmei, Yang, Jingmin, Wang, Mengyun, Qiu, Lixin, Zheng, Yabiao, Zhang, Ping, Li, Jin, Wang, Ya’nong, Wei, Qingyi, Jin, Li, Wang, Jiucun, Wang, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063769/
https://www.ncbi.nlm.nih.gov/pubmed/24945256
http://dx.doi.org/10.1371/journal.pone.0100055
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author Zhang, Junjie
Huang, Xuewen
Xiao, Juanjuan
Yang, Yajun
Zhou, Yinghui
Wang, Xiaofeng
Liu, Qingmei
Yang, Jingmin
Wang, Mengyun
Qiu, Lixin
Zheng, Yabiao
Zhang, Ping
Li, Jin
Wang, Ya’nong
Wei, Qingyi
Jin, Li
Wang, Jiucun
Wang, Minghua
author_facet Zhang, Junjie
Huang, Xuewen
Xiao, Juanjuan
Yang, Yajun
Zhou, Yinghui
Wang, Xiaofeng
Liu, Qingmei
Yang, Jingmin
Wang, Mengyun
Qiu, Lixin
Zheng, Yabiao
Zhang, Ping
Li, Jin
Wang, Ya’nong
Wei, Qingyi
Jin, Li
Wang, Jiucun
Wang, Minghua
author_sort Zhang, Junjie
collection PubMed
description MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43–0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. TT/TC: p = 0.007, OR = 0.82, 95% CI = 0.71–0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.
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spelling pubmed-40637692014-06-25 Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations Zhang, Junjie Huang, Xuewen Xiao, Juanjuan Yang, Yajun Zhou, Yinghui Wang, Xiaofeng Liu, Qingmei Yang, Jingmin Wang, Mengyun Qiu, Lixin Zheng, Yabiao Zhang, Ping Li, Jin Wang, Ya’nong Wei, Qingyi Jin, Li Wang, Jiucun Wang, Minghua PLoS One Research Article MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43–0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. TT/TC: p = 0.007, OR = 0.82, 95% CI = 0.71–0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population. Public Library of Science 2014-06-19 /pmc/articles/PMC4063769/ /pubmed/24945256 http://dx.doi.org/10.1371/journal.pone.0100055 Text en © 2014 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Junjie
Huang, Xuewen
Xiao, Juanjuan
Yang, Yajun
Zhou, Yinghui
Wang, Xiaofeng
Liu, Qingmei
Yang, Jingmin
Wang, Mengyun
Qiu, Lixin
Zheng, Yabiao
Zhang, Ping
Li, Jin
Wang, Ya’nong
Wei, Qingyi
Jin, Li
Wang, Jiucun
Wang, Minghua
Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations
title Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations
title_full Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations
title_fullStr Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations
title_full_unstemmed Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations
title_short Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations
title_sort pri-mir-124 rs531564 and pri-mir-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in chinese populations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063769/
https://www.ncbi.nlm.nih.gov/pubmed/24945256
http://dx.doi.org/10.1371/journal.pone.0100055
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