Phenotype of Transgenic Mice Carrying a Very Low Copy Number of the Mutant Human G93A Superoxide Dismutase-1 Gene Associated with Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neuron. While most cases of ALS are sporadic, 10% are familial (FALS) with 20% of FALS caused by a mutation in the gene that codes for the enzyme Cu/Zn superoxide dismutase (SOD1). There is variability in spo...

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Detalles Bibliográficos
Autores principales: Deitch, Jeffrey S., Alexander, Guillermo M., Bensinger, Andrew, Yang, Steven, Jiang, Juliann T., Heiman-Patterson, Terry D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063781/
https://www.ncbi.nlm.nih.gov/pubmed/24945277
http://dx.doi.org/10.1371/journal.pone.0099879

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