Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways

Chemoresistance is a major cause of cancer treatment failure and leads to a reduction in the survival rate of cancer patients. Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and mitogen-activated protein kinase (MAPK) pathways are aberrantly activated in...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Xiao Li, Lin, Feng Juan, Guo, Ya Jie, Shao, Zhi Min, Ou, Zhou Luo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063800/
https://www.ncbi.nlm.nih.gov/pubmed/24966685
http://dx.doi.org/10.2147/OTT.S63145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063800/
https://www.ncbi.nlm.nih.gov/pubmed/24966685
http://dx.doi.org/10.2147/OTT.S63145

Ejemplares similares