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Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways

Chemoresistance is a major cause of cancer treatment failure and leads to a reduction in the survival rate of cancer patients. Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and mitogen-activated protein kinase (MAPK) pathways are aberrantly activated in...

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Detalles Bibliográficos
Autores principales:	Yang, Xiao Li, Lin, Feng Juan, Guo, Ya Jie, Shao, Zhi Min, Ou, Zhou Luo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063800/ https://www.ncbi.nlm.nih.gov/pubmed/24966685 http://dx.doi.org/10.2147/OTT.S63145

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