MAGI: Methylation analysis using genome information

By incorporating annotation information into the analysis of next-generation sequencing DNA methylation data, we provide an improvement in performance over current testing procedures. Methylation analysis using genome information (MAGI) is applicable for both unreplicated and replicated data, and pr...

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Detalles Bibliográficos
Autores principales: Baumann, Douglas D, Doerge, RW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063829/
https://www.ncbi.nlm.nih.gov/pubmed/24589664
http://dx.doi.org/10.4161/epi.28322
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author Baumann, Douglas D
Doerge, RW
author_facet Baumann, Douglas D
Doerge, RW
author_sort Baumann, Douglas D
collection PubMed
description By incorporating annotation information into the analysis of next-generation sequencing DNA methylation data, we provide an improvement in performance over current testing procedures. Methylation analysis using genome information (MAGI) is applicable for both unreplicated and replicated data, and provides an effective analysis for studies with low sequencing depth. When compared with current tests, the annotation-informed tests provide an increase in statistical power and offer a significance-based interpretation of differential methylation.
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spelling pubmed-40638292015-05-01 MAGI: Methylation analysis using genome information Baumann, Douglas D Doerge, RW Epigenetics Brief Report By incorporating annotation information into the analysis of next-generation sequencing DNA methylation data, we provide an improvement in performance over current testing procedures. Methylation analysis using genome information (MAGI) is applicable for both unreplicated and replicated data, and provides an effective analysis for studies with low sequencing depth. When compared with current tests, the annotation-informed tests provide an increase in statistical power and offer a significance-based interpretation of differential methylation. Landes Bioscience 2014-05-01 2014-03-31 /pmc/articles/PMC4063829/ /pubmed/24589664 http://dx.doi.org/10.4161/epi.28322 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Brief Report
Baumann, Douglas D
Doerge, RW
MAGI: Methylation analysis using genome information
title MAGI: Methylation analysis using genome information
title_full MAGI: Methylation analysis using genome information
title_fullStr MAGI: Methylation analysis using genome information
title_full_unstemmed MAGI: Methylation analysis using genome information
title_short MAGI: Methylation analysis using genome information
title_sort magi: methylation analysis using genome information
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063829/
https://www.ncbi.nlm.nih.gov/pubmed/24589664
http://dx.doi.org/10.4161/epi.28322
work_keys_str_mv AT baumanndouglasd magimethylationanalysisusinggenomeinformation
AT doergerw magimethylationanalysisusinggenomeinformation

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