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Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics
The human gut microbiota plays a key role in pharmacology, yet the mechanisms responsible remain unclear, impeding efforts toward personalized medicine. We recently identified a cytochrome-encoding operon in the common gut Actinobacterium Eggerthella lenta that is transcriptionally activated by the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063850/ https://www.ncbi.nlm.nih.gov/pubmed/24637603 http://dx.doi.org/10.4161/gmic.27915 |