Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis

Nfatc2 and Tob1 are intrinsic negative regulators of T cell activation. Nfatc2-deficient and Tob1-deficient T cells show reduced thresholds of activation; however, whether these factors have independent or overlapping roles in negative regulation of T cell responses has not been previously examined....

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Detalles Bibliográficos
Autores principales: May, Sarah L., Zhou, Qing, Lewellen, Mitzi, Carter, Cristan M., Coffey, David, Highfill, Steven L., Bucher, Christoph M., Matise, Ilze, Morse, Herbert C., O’Sullivan, M. Gerard, Schutten, Melissa, Johnson, Charles, Bellgrau, Donald, Blazar, Bruce R., Modiano, Jaime F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063948/
https://www.ncbi.nlm.nih.gov/pubmed/24945807
http://dx.doi.org/10.1371/journal.pone.0100629

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