Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat

Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in...

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Autores principales: WATANABE, Shinya, ITO, Jumpei, BABA, Takuya, HIRATSUKA, Takahiro, KUSE, Kyohei, OCHI, Haruyo, ANAI, Yukari, HISASUE, Masaharu, TSUJIMOTO, Hajime, NISHIGAKI, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2013
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064141/
https://www.ncbi.nlm.nih.gov/pubmed/24317268
http://dx.doi.org/10.1292/jvms.13-0344
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author WATANABE, Shinya
ITO, Jumpei
BABA, Takuya
HIRATSUKA, Takahiro
KUSE, Kyohei
OCHI, Haruyo
ANAI, Yukari
HISASUE, Masaharu
TSUJIMOTO, Hajime
NISHIGAKI, Kazuo
author_facet WATANABE, Shinya
ITO, Jumpei
BABA, Takuya
HIRATSUKA, Takahiro
KUSE, Kyohei
OCHI, Haruyo
ANAI, Yukari
HISASUE, Masaharu
TSUJIMOTO, Hajime
NISHIGAKI, Kazuo
author_sort WATANABE, Shinya
collection PubMed
description Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.
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spelling pubmed-40641412014-06-25 Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat WATANABE, Shinya ITO, Jumpei BABA, Takuya HIRATSUKA, Takahiro KUSE, Kyohei OCHI, Haruyo ANAI, Yukari HISASUE, Masaharu TSUJIMOTO, Hajime NISHIGAKI, Kazuo J Vet Med Sci Virology Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma. The Japanese Society of Veterinary Science 2013-12-09 2014-04 /pmc/articles/PMC4064141/ /pubmed/24317268 http://dx.doi.org/10.1292/jvms.13-0344 Text en ©2014 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Virology
WATANABE, Shinya
ITO, Jumpei
BABA, Takuya
HIRATSUKA, Takahiro
KUSE, Kyohei
OCHI, Haruyo
ANAI, Yukari
HISASUE, Masaharu
TSUJIMOTO, Hajime
NISHIGAKI, Kazuo
Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
title Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
title_full Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
title_fullStr Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
title_full_unstemmed Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
title_short Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
title_sort notch2 transduction by feline leukemia virus in a naturally infected cat
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064141/
https://www.ncbi.nlm.nih.gov/pubmed/24317268
http://dx.doi.org/10.1292/jvms.13-0344
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