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Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation

High-throughput prioritization of cancer-causing mutations (drivers) is a key challenge of cancer genome projects, due to the number of somatic variants detected in tumors. One important step in this task is to assess the functional impact of tumor somatic mutations. A number of computational method...

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Detalles Bibliográficos
Autores principales: Gonzalez-Perez, Abel, Deu-Pons, Jordi, Lopez-Bigas, Nuria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064314/
https://www.ncbi.nlm.nih.gov/pubmed/23181723
http://dx.doi.org/10.1186/gm390