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Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules

“The incidence of thyroid cancer, the most common endocrine malignancy, is rising. The two most common types of thyroid cancer are papillary and follicular” thyroid carcinomas. “Fine-needle aspiration (FNA) of thyroid nodules” can permit to detect many genetic mutations and other molecular alteratio...

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Autores principales: Fallahi, Poupak, Giannini, Riccardo, Miccoli, Paolo, Antonelli, Alessandro, Basolo, Fulvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064556/
https://www.ncbi.nlm.nih.gov/pubmed/24955024
http://dx.doi.org/10.2174/1389202915999140404100347
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author Fallahi, Poupak
Giannini, Riccardo
Miccoli, Paolo
Antonelli, Alessandro
Basolo, Fulvio
author_facet Fallahi, Poupak
Giannini, Riccardo
Miccoli, Paolo
Antonelli, Alessandro
Basolo, Fulvio
author_sort Fallahi, Poupak
collection PubMed
description “The incidence of thyroid cancer, the most common endocrine malignancy, is rising. The two most common types of thyroid cancer are papillary and follicular” thyroid carcinomas. “Fine-needle aspiration (FNA) of thyroid nodules” can permit to detect many genetic mutations and other molecular alterations, including RAS and BRAF point mutations, PAX8/peroxisome proliferator-activated receptor (PPAR)γ and “RET/PTC rearrangements, occurring in thyroid papillary and follicular carcinomas” (more than 70% of cases), which can be used successfully to improve the diagnosis “and the management of patients with thyroid nodules”. The most extensive experience has been accumulated with “the diagnostic use of BRAF mutation”, which is highly specific for malignancy. “Testing FNA samples for a panel of mutations” that typically includes RAS, BRAF, PAX8/PPARγ and RET/PTC could permit to achieve the biggest diagnostic impact. “The accuracy of cancer diagnosis in thyroid nodules could be improved significantly using these and other emerging molecular markers”.
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spelling pubmed-40645562014-12-01 Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules Fallahi, Poupak Giannini, Riccardo Miccoli, Paolo Antonelli, Alessandro Basolo, Fulvio Curr Genomics Article “The incidence of thyroid cancer, the most common endocrine malignancy, is rising. The two most common types of thyroid cancer are papillary and follicular” thyroid carcinomas. “Fine-needle aspiration (FNA) of thyroid nodules” can permit to detect many genetic mutations and other molecular alterations, including RAS and BRAF point mutations, PAX8/peroxisome proliferator-activated receptor (PPAR)γ and “RET/PTC rearrangements, occurring in thyroid papillary and follicular carcinomas” (more than 70% of cases), which can be used successfully to improve the diagnosis “and the management of patients with thyroid nodules”. The most extensive experience has been accumulated with “the diagnostic use of BRAF mutation”, which is highly specific for malignancy. “Testing FNA samples for a panel of mutations” that typically includes RAS, BRAF, PAX8/PPARγ and RET/PTC could permit to achieve the biggest diagnostic impact. “The accuracy of cancer diagnosis in thyroid nodules could be improved significantly using these and other emerging molecular markers”. Bentham Science Publishers 2014-06 2014-06 /pmc/articles/PMC4064556/ /pubmed/24955024 http://dx.doi.org/10.2174/1389202915999140404100347 Text en ©2014 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Fallahi, Poupak
Giannini, Riccardo
Miccoli, Paolo
Antonelli, Alessandro
Basolo, Fulvio
Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
title Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
title_full Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
title_fullStr Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
title_full_unstemmed Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
title_short Molecular Diagnostics of Fine Needle Aspiration for the Presurgical Screening of Thyroid Nodules
title_sort molecular diagnostics of fine needle aspiration for the presurgical screening of thyroid nodules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064556/
https://www.ncbi.nlm.nih.gov/pubmed/24955024
http://dx.doi.org/10.2174/1389202915999140404100347
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