Cargando…

Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene

The completion of the Human Genome Project aroused renewed interest in alternative splicing, an efficient and widespread mechanism that generates multiple protein isoforms from individual genes. Although our knowledge about alternative splicing is growing exponentially, its real impact on cellular l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cognata, Valentina La, Iemmolo, Rosario, D’Agata, Velia, Scuderi, Soraya, Drago, Filippo, Zappia, Mario, Cavallaro, Sebastiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064560/ https://www.ncbi.nlm.nih.gov/pubmed/24955028 http://dx.doi.org/10.2174/1389202915666140426003342

Ejemplares similares

Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain
por: Scuderi, Soraya, et al.
Publicado: (2014)

Splicing: is there an alternative contribution to Parkinson’s disease?
por: La Cognata, Valentina, et al.
Publicado: (2015)

Cracking the Code of Neuronal Cell Fate
por: Morello, Giovanna, et al.
Publicado: (2023)

Copy number variability in Parkinson’s disease: assembling the puzzle through a systems biology approach
por: La Cognata, Valentina, et al.
Publicado: (2016)

NeuroArray, A Custom CGH Microarray to Decipher Copy Number Variants in Alzheimer’s Disease
por: Cuccaro, Denis, et al.
Publicado: (2018)

iPSCs: A Preclinical Drug Research Tool for Neurological Disorders
por: Bonaventura, Gabriele, et al.
Publicado: (2021)

Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach
por: Morello, Giovanna, et al.
Publicado: (2017)

A customized high-resolution array-comparative genomic hybridization to explore copy number variations in Parkinson’s disease
por: La Cognata, Valentina, et al.
Publicado: (2016)

Development of a Pharmacogenetic Lab-on-Chip Assay Based on the In-Check Technology to Screen for Genetic Variations Associated to Adverse Drug Reactions to Common Chemotherapeutic Agents
por: Iemmolo, Rosario, et al.
Publicado: (2020)

CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A
por: La Cognata, Valentina, et al.
Publicado: (2023)

The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells
por: La Cognata, Valentina, et al.
Publicado: (2023)

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions
por: La Cognata, Valentina, et al.
Publicado: (2020)

Effect of a Bone Marrow-Derived Extracellular Matrix on Cell Adhesion and Neural Induction of Dental Pulp Stem Cells
por: Laudani, Samuele, et al.
Publicado: (2020)

Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival
por: Morello, Giovanna, et al.
Publicado: (2021)

Biocompatibility between Silicon or Silicon Carbide surface and Neural Stem Cells
por: Bonaventura, Gabriele, et al.
Publicado: (2019)

A Comprehensive, Targeted NGS Approach to Assessing Molecular Diagnosis of Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2021)

Detection of Structural Variants by NGS: Revealing Missing Alleles in Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2022)

From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2020)

Highlights on Genomics Applications for Lysosomal Storage Diseases
por: La Cognata, Valentina, et al.
Publicado: (2020)

Omics Data and Their Integrative Analysis to Support Stratified Medicine in Neurodegenerative Diseases
por: La Cognata, Valentina, et al.
Publicado: (2021)

Selection and Prioritization of Candidate Drug Targets for Amyotrophic Lateral Sclerosis Through a Meta-Analysis Approach
por: Morello, Giovanna, et al.
Publicado: (2017)

Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP
por: Maugeri, Grazia, et al.
Publicado: (2020)

NeuroArray: A Customized aCGH for the Analysis of Copy Number Variations in Neurological Disorders
por: La Cognata, Valentina, et al.
Publicado: (2018)

Design and Validation of a Custom NGS Panel Targeting a Set of Lysosomal Storage Diseases Candidate for NBS Applications
por: La Cognata, Valentina, et al.
Publicado: (2021)

PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression
por: Maugeri, Grazia, et al.
Publicado: (2016)

PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis
por: D’Amico, Agata Grazia, et al.
Publicado: (2020)

Corneal wound healing and nerve regeneration by novel ophthalmic formulations based on cross-linked sodium hyaluronate, taurine, vitamin B6, and vitamin B12
por: Bucolo, Claudio, et al.
Publicado: (2023)

Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases?
por: Bonaventura, Gabriele, et al.
Publicado: (2021)

Miniaturized Real-Time PCR on a Q3 System for Rapid KRAS Genotyping
por: Guarnaccia, Maria, et al.
Publicado: (2017)

Potential role of probiotics on colorectal cancer prevention
por: Uccello, Mario, et al.
Publicado: (2012)

Genotyping of KRAS Mutational Status by the In-Check Lab-on-Chip Platform
por: Guarnaccia, Maria, et al.
Publicado: (2018)

Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS
por: Morello, Giovanna, et al.
Publicado: (2019)

Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition
por: Maugeri, Grazia, et al.
Publicado: (2021)

Effects of Physical Activity on Amyotrophic Lateral Sclerosis
por: Maugeri, Grazia, et al.
Publicado: (2020)

Elevated serum levels of Chromogranin A in hepatocellular carcinoma
por: Biondi, Antonio, et al.
Publicado: (2012)

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment
por: Morello, Giovanna, et al.
Publicado: (2023)

A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2023)

Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
por: Gentile, Giulia, et al.
Publicado: (2022)

Coding potential of the products of alternative splicing in human
por: Leoni, Guido, et al.
Publicado: (2011)

Centenarians and supercentenarians: a black swan. Emerging social, medical and surgical problems
por: Vacante, Marco, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_3918iamfp34ml13dkq40rmffa7