Dendritic cells during Epstein Barr virus infection

Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This γ-herpes virus infects primarily human B and epithelial cells, but it has been reported to be sensed by dendritic cells (DCs) during primary inf...

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Detalles Bibliográficos
Autor principal: Christian, Münz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064564/
https://www.ncbi.nlm.nih.gov/pubmed/24999343
http://dx.doi.org/10.3389/fmicb.2014.00308
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author Christian, Münz
author_facet Christian, Münz
author_sort Christian, Münz
collection PubMed
description Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This γ-herpes virus infects primarily human B and epithelial cells, but it has been reported to be sensed by dendritic cells (DCs) during primary infection. These activated DCs are thought to contribute to innate restriction of EBV infection and initiate EBV-specific adaptive immune responses via cross-priming. The respective evidence and their potential importance for EBV-specific vaccine development will be discussed in this review.
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spelling pubmed-40645642014-07-04 Dendritic cells during Epstein Barr virus infection Christian, Münz Front Microbiol Neuroscience Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This γ-herpes virus infects primarily human B and epithelial cells, but it has been reported to be sensed by dendritic cells (DCs) during primary infection. These activated DCs are thought to contribute to innate restriction of EBV infection and initiate EBV-specific adaptive immune responses via cross-priming. The respective evidence and their potential importance for EBV-specific vaccine development will be discussed in this review. Frontiers Media S.A. 2014-06-20 /pmc/articles/PMC4064564/ /pubmed/24999343 http://dx.doi.org/10.3389/fmicb.2014.00308 Text en Copyright © 2014 Münz. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Christian, Münz
Dendritic cells during Epstein Barr virus infection
title Dendritic cells during Epstein Barr virus infection
title_full Dendritic cells during Epstein Barr virus infection
title_fullStr Dendritic cells during Epstein Barr virus infection
title_full_unstemmed Dendritic cells during Epstein Barr virus infection
title_short Dendritic cells during Epstein Barr virus infection
title_sort dendritic cells during epstein barr virus infection
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064564/
https://www.ncbi.nlm.nih.gov/pubmed/24999343
http://dx.doi.org/10.3389/fmicb.2014.00308
work_keys_str_mv AT christianmunz dendriticcellsduringepsteinbarrvirusinfection

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