Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation

[Image: see text] The design of novel chemoselective and site-specific ligation methods provides new tools for obtaining complex scaffolds, peptidomimetics, and peptide conjugates. The chemistry of the N-phenylthiocarbonyl group has led to several developments in peptide ligation chemistry and pepti...

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Autores principales: Melnyk, Oleg, Ollivier, Nathalie, Besret, Soizic, Melnyk, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064696/
https://www.ncbi.nlm.nih.gov/pubmed/24641212
http://dx.doi.org/10.1021/bc500052r
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author Melnyk, Oleg
Ollivier, Nathalie
Besret, Soizic
Melnyk, Patricia
author_facet Melnyk, Oleg
Ollivier, Nathalie
Besret, Soizic
Melnyk, Patricia
author_sort Melnyk, Oleg
collection PubMed
description [Image: see text] The design of novel chemoselective and site-specific ligation methods provides new tools for obtaining complex scaffolds, peptidomimetics, and peptide conjugates. The chemistry of the N-phenylthiocarbonyl group has led to several developments in peptide ligation chemistry and peptide bioconjugation during the last 10 years. The aim of this review is to provide an overview of this emerging field.
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spelling pubmed-40646962015-03-18 Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation Melnyk, Oleg Ollivier, Nathalie Besret, Soizic Melnyk, Patricia Bioconjug Chem [Image: see text] The design of novel chemoselective and site-specific ligation methods provides new tools for obtaining complex scaffolds, peptidomimetics, and peptide conjugates. The chemistry of the N-phenylthiocarbonyl group has led to several developments in peptide ligation chemistry and peptide bioconjugation during the last 10 years. The aim of this review is to provide an overview of this emerging field. American Chemical Society 2014-03-18 2014-04-16 /pmc/articles/PMC4064696/ /pubmed/24641212 http://dx.doi.org/10.1021/bc500052r Text en Copyright © 2014 American Chemical Society Open Access on 03/18/2015
spellingShingle Melnyk, Oleg
Ollivier, Nathalie
Besret, Soizic
Melnyk, Patricia
Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
title Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
title_full Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
title_fullStr Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
title_full_unstemmed Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
title_short Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
title_sort phenylthiocarbamate or n-carbothiophenyl group chemistry in peptide synthesis and bioconjugation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064696/
https://www.ncbi.nlm.nih.gov/pubmed/24641212
http://dx.doi.org/10.1021/bc500052r
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AT melnykpatricia phenylthiocarbamateorncarbothiophenylgroupchemistryinpeptidesynthesisandbioconjugation

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