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On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight

This article is part of a Special Issue “Energy Balance”. Seasonal cycles of adiposity and body weight reflecting changes in both food intake and energy expenditure are the norm in mammals that have evolved in temperate and polar habitats. Innate circannual rhythmicity and direct responses to the an...

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Autor principal: Ebling, Francis J.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064697/
https://www.ncbi.nlm.nih.gov/pubmed/24681216
http://dx.doi.org/10.1016/j.yhbeh.2014.03.009
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author Ebling, Francis J.P.
author_facet Ebling, Francis J.P.
author_sort Ebling, Francis J.P.
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description This article is part of a Special Issue “Energy Balance”. Seasonal cycles of adiposity and body weight reflecting changes in both food intake and energy expenditure are the norm in mammals that have evolved in temperate and polar habitats. Innate circannual rhythmicity and direct responses to the annual change in photoperiod combine to ensure that behavior and energy metabolism are regulated in anticipation of altered energetic demands such as the energetically costly processes of hibernation, migration, and lactation. In the last decade, major progress has been made into identifying the central mechanisms that underlie these profound long-term changes in behavior and physiology. Surprisingly they are distinct from the peptidergic and aminergic systems in the hypothalamus that have been identified in studies of the laboratory mouse and rat and implicated in timing meal intervals and in short-term responses to caloric restriction. Comparative studies across rodents, ungulates and birds reveal that tanycytes embedded in the ependymal layer of the third ventricle play a critical role in seasonal changes because they regulate the local availability of thyroid hormone. Understanding how this altered hormonal environment might regulate neurogenesis and plasticity in the hypothalamus should provide new insight into development of strategies to manage appetite and body weight.
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spelling pubmed-40646972014-06-23 On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight Ebling, Francis J.P. Horm Behav Review This article is part of a Special Issue “Energy Balance”. Seasonal cycles of adiposity and body weight reflecting changes in both food intake and energy expenditure are the norm in mammals that have evolved in temperate and polar habitats. Innate circannual rhythmicity and direct responses to the annual change in photoperiod combine to ensure that behavior and energy metabolism are regulated in anticipation of altered energetic demands such as the energetically costly processes of hibernation, migration, and lactation. In the last decade, major progress has been made into identifying the central mechanisms that underlie these profound long-term changes in behavior and physiology. Surprisingly they are distinct from the peptidergic and aminergic systems in the hypothalamus that have been identified in studies of the laboratory mouse and rat and implicated in timing meal intervals and in short-term responses to caloric restriction. Comparative studies across rodents, ungulates and birds reveal that tanycytes embedded in the ependymal layer of the third ventricle play a critical role in seasonal changes because they regulate the local availability of thyroid hormone. Understanding how this altered hormonal environment might regulate neurogenesis and plasticity in the hypothalamus should provide new insight into development of strategies to manage appetite and body weight. Academic Press 2014-06 /pmc/articles/PMC4064697/ /pubmed/24681216 http://dx.doi.org/10.1016/j.yhbeh.2014.03.009 Text en © 2014 The Author http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ebling, Francis J.P.
On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
title On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
title_full On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
title_fullStr On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
title_full_unstemmed On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
title_short On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
title_sort on the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064697/
https://www.ncbi.nlm.nih.gov/pubmed/24681216
http://dx.doi.org/10.1016/j.yhbeh.2014.03.009
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