Cargando…

A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol

Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoper...

Descripción completa

Detalles Bibliográficos
Autores principales: Brierley, Rachel C.M., Pike, Katie, Miles, Alice, Wordsworth, Sarah, Stokes, Elizabeth A., Mumford, Andrew D., Cohen, Alan, Angelini, Gianni D., Murphy, Gavin J., Rogers, Chris A., Reeves, Barnaby C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon, Elsevier Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064699/
https://www.ncbi.nlm.nih.gov/pubmed/24675014
http://dx.doi.org/10.1016/j.transci.2014.02.020
Descripción
Sumario:Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.