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Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome

OBJECTIVE: The aim of this study is to determine if simvastatin pretreatment would change clomiphene response in clomiphene citrate-resistant (CC-R)women with (PCOS). MATERIALS AND METHODS: This quasi experimental study included twenty five clomiphene resistant women with PCOS. All patients received...

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Autores principales: Azargoon, Azam, Ghorbani, Raheb, Faraji, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064748/
https://www.ncbi.nlm.nih.gov/pubmed/24971120
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author Azargoon, Azam
Ghorbani, Raheb
Faraji, Zahra
author_facet Azargoon, Azam
Ghorbani, Raheb
Faraji, Zahra
author_sort Azargoon, Azam
collection PubMed
description OBJECTIVE: The aim of this study is to determine if simvastatin pretreatment would change clomiphene response in clomiphene citrate-resistant (CC-R)women with (PCOS). MATERIALS AND METHODS: This quasi experimental study included twenty five clomiphene resistant women with PCOS. All patients received cyclic oral contraceptives pills (OCP) (30µg of ethinyl estradiol and 150µg of desogestrol) from the 5th day of their spontaneous or progesterone (P) induced menstrual cycle; in addition, they received simvastatin (20mg/day) from the first day of cycle for two consecutive months. Then, patients were given 100 mg clomiphene citrate (CC) (Iran Hormone, Iran) for five days starting from day three of their menstrual cycles. The primary outcome measures were ovulation and pregnancy rates. The change in body mass index (BMI), the mean number of follicles ≥ 18 mm, the mean of follicular size and endometrial thickness on the day of human chorionic gonadotropin (HCG) administration were secondary outcome measures. RESULTS: Ovulation occurred in 5 out of 25 (20%) patients, but none of the patients conceived in this study. No important change in BMI was observed after using simvastatin (0.28 + 1.13; p = 0.228). In all patients with ovulation, the number of follicles ≥ 18mm was one. The mean follicular size and endometrial thickness on the day of HCG administration were 19.67 ± 2.04 and 7.00 ± 1.34, respectively. CONCLUSION: In this study, we did not observe the favorable effect on ovulation and pregnancy rates with CC following of simvastatin pretreatment in CC-resistant PCOS women. So, further studies with a larger number of patients, higher doses of CC and more cycles are necessary to make this obvious.
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spelling pubmed-40647482014-06-26 Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome Azargoon, Azam Ghorbani, Raheb Faraji, Zahra J Family Reprod Health Original Article OBJECTIVE: The aim of this study is to determine if simvastatin pretreatment would change clomiphene response in clomiphene citrate-resistant (CC-R)women with (PCOS). MATERIALS AND METHODS: This quasi experimental study included twenty five clomiphene resistant women with PCOS. All patients received cyclic oral contraceptives pills (OCP) (30µg of ethinyl estradiol and 150µg of desogestrol) from the 5th day of their spontaneous or progesterone (P) induced menstrual cycle; in addition, they received simvastatin (20mg/day) from the first day of cycle for two consecutive months. Then, patients were given 100 mg clomiphene citrate (CC) (Iran Hormone, Iran) for five days starting from day three of their menstrual cycles. The primary outcome measures were ovulation and pregnancy rates. The change in body mass index (BMI), the mean number of follicles ≥ 18 mm, the mean of follicular size and endometrial thickness on the day of human chorionic gonadotropin (HCG) administration were secondary outcome measures. RESULTS: Ovulation occurred in 5 out of 25 (20%) patients, but none of the patients conceived in this study. No important change in BMI was observed after using simvastatin (0.28 + 1.13; p = 0.228). In all patients with ovulation, the number of follicles ≥ 18mm was one. The mean follicular size and endometrial thickness on the day of HCG administration were 19.67 ± 2.04 and 7.00 ± 1.34, respectively. CONCLUSION: In this study, we did not observe the favorable effect on ovulation and pregnancy rates with CC following of simvastatin pretreatment in CC-resistant PCOS women. So, further studies with a larger number of patients, higher doses of CC and more cycles are necessary to make this obvious. Tehran University of Medical Sciences 2013-12 /pmc/articles/PMC4064748/ /pubmed/24971120 Text en Copyright © Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Azargoon, Azam
Ghorbani, Raheb
Faraji, Zahra
Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome
title Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome
title_full Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome
title_fullStr Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome
title_full_unstemmed Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome
title_short Effects of Simvastatin Pretreatment on Clomiphene Response in Clomiphene – Resistant Women with Polycystic Ovary Syndrome
title_sort effects of simvastatin pretreatment on clomiphene response in clomiphene – resistant women with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064748/
https://www.ncbi.nlm.nih.gov/pubmed/24971120
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