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Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity

Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation reactions employed by ATP-dependent DNA ligases(1,2). Paradoxically, when DNA ligases encounter nicked DNA structures with abnormal DNA termini, DNA ligase catalytic activity can generate and/or exacerba...

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Detalles Bibliográficos
Autores principales:	Tumbale, Percy, Williams, Jessica S., Schellenberg, Matthew J., Kunkel, Thomas A., Williams, R. Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064939/ https://www.ncbi.nlm.nih.gov/pubmed/24362567 http://dx.doi.org/10.1038/nature12824

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