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Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner

Metformin is a widely prescribed drug for the treatment of type 2 diabetes. Previous studies have demonstrated in vitro that metformin specifically inhibits Complex I of the mitochondrial respiratory chain. This seems contraindicative since muscle mitochondrial dysfunction has been linked to the pat...

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Detalles Bibliográficos
Autores principales:	Wessels, Bart, Ciapaite, Jolita, van den Broek, Nicole M. A., Nicolay, Klaas, Prompers, Jeanine J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065055/ https://www.ncbi.nlm.nih.gov/pubmed/24950069 http://dx.doi.org/10.1371/journal.pone.0100525

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