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Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia

BACKGROUND: Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 and Neuregulin 3 have been reported to contribute to an increased risk for develo...

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Autores principales: Díez, Álvaro, Cieza-Borrella, Clara, Suazo, Vanessa, González-Sarmiento, Rogelio, Papiol, Sergi, Molina, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065086/
https://www.ncbi.nlm.nih.gov/pubmed/24976857
http://dx.doi.org/10.1186/1744-859X-13-18
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author Díez, Álvaro
Cieza-Borrella, Clara
Suazo, Vanessa
González-Sarmiento, Rogelio
Papiol, Sergi
Molina, Vicente
author_facet Díez, Álvaro
Cieza-Borrella, Clara
Suazo, Vanessa
González-Sarmiento, Rogelio
Papiol, Sergi
Molina, Vicente
author_sort Díez, Álvaro
collection PubMed
description BACKGROUND: Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 and Neuregulin 3 have been reported to contribute to an increased risk for developing schizophrenia. We hypothesized that three specific variants of these genes (rs6994992 and rs3924999 for Neuregulin 1 and rs10748842 for Neuregulin 3) that have been related to this illness may modify information processing capacity in the cortex, which would be reflected in electrophysiological parameters (P3b amplitude or gamma noise power) and/or cognitive performance. METHODS: We obtained DNA from 31 patients with schizophrenia and 23 healthy controls and analyzed NRG1 rs6994992, NRG1 rs3924999 and NRG3 rs10748842 promoter polymorphisms by allelic discrimination with real-time polymerase chain reaction (PCR). We compared cognitive outcome, P300 amplitude parameters and an electroencephalographic measure of noise power in the gamma band between the groups dichotomized according to genotype. RESULTS: Contrary to our hypothesis, we could not detect any significant influence of variation in Neuregulin 1/Neuregulin 3 polymorphisms on cognitive performance or electrophysiological parameters of patients with schizophrenia. CONCLUSIONS: Despite our findings, we cannot discard that other genetic variants and, more likely, interactions between those variants and with genetic variation related to different pathways may still influence cerebral processing in schizophrenia.
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spelling pubmed-40650862014-06-27 Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia Díez, Álvaro Cieza-Borrella, Clara Suazo, Vanessa González-Sarmiento, Rogelio Papiol, Sergi Molina, Vicente Ann Gen Psychiatry Primary Research BACKGROUND: Neuregulins are a family of signalling proteins that orchestrate a broad range of cellular responses. Four genes encoding Neuregulins 1–4 have been identified so far in vertebrates. Among them, Neuregulin 1 and Neuregulin 3 have been reported to contribute to an increased risk for developing schizophrenia. We hypothesized that three specific variants of these genes (rs6994992 and rs3924999 for Neuregulin 1 and rs10748842 for Neuregulin 3) that have been related to this illness may modify information processing capacity in the cortex, which would be reflected in electrophysiological parameters (P3b amplitude or gamma noise power) and/or cognitive performance. METHODS: We obtained DNA from 31 patients with schizophrenia and 23 healthy controls and analyzed NRG1 rs6994992, NRG1 rs3924999 and NRG3 rs10748842 promoter polymorphisms by allelic discrimination with real-time polymerase chain reaction (PCR). We compared cognitive outcome, P300 amplitude parameters and an electroencephalographic measure of noise power in the gamma band between the groups dichotomized according to genotype. RESULTS: Contrary to our hypothesis, we could not detect any significant influence of variation in Neuregulin 1/Neuregulin 3 polymorphisms on cognitive performance or electrophysiological parameters of patients with schizophrenia. CONCLUSIONS: Despite our findings, we cannot discard that other genetic variants and, more likely, interactions between those variants and with genetic variation related to different pathways may still influence cerebral processing in schizophrenia. BioMed Central 2014-06-14 /pmc/articles/PMC4065086/ /pubmed/24976857 http://dx.doi.org/10.1186/1744-859X-13-18 Text en Copyright © 2014 Díez et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Primary Research
Díez, Álvaro
Cieza-Borrella, Clara
Suazo, Vanessa
González-Sarmiento, Rogelio
Papiol, Sergi
Molina, Vicente
Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
title Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
title_full Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
title_fullStr Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
title_full_unstemmed Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
title_short Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
title_sort cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065086/
https://www.ncbi.nlm.nih.gov/pubmed/24976857
http://dx.doi.org/10.1186/1744-859X-13-18
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