Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting

In mammals, genomic imprinting governed by DNA methyltransferase DNMT3A and its cofactor DNMT3L is essential for functional gametes. Oocyte-specific methylation imprints are established during oocyte growth concomitant with DNMT3A/DNMT3L expression, although the mechanisms of oocyte-specific imprint...

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Detalles Bibliográficos
Autores principales: Hara, Satoshi, Takano, Takashi, Fujikawa, Tsugunari, Yamada, Munehiro, Wakai, Takuya, Kono, Tomohiro, Obata, Yayoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065157/
https://www.ncbi.nlm.nih.gov/pubmed/24599402
http://dx.doi.org/10.1093/hmg/ddu100

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