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Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus

[Image: see text] The thermal melting temperature of dihydrofolate reductase from Geobacillus stearothermophilus (BsDHFR) is ∼30 °C higher than that of its homologue from the psychrophile Moritella profunda. Additional proline residues in the loop regions of BsDHFR have been proposed to enhance the...

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Detalles Bibliográficos
Autores principales:	Guo, Jiannan, Luk, Louis Y. P., Loveridge, E. Joel, Allemann, Rudolf K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065160/ https://www.ncbi.nlm.nih.gov/pubmed/24730604 http://dx.doi.org/10.1021/bi500238q

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