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Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases

To investigate the association of CLEC16A gene polymorphisms and autoimmune thyroid diseases (AITDs). Six hundred sixty seven Han Chinese patients with AITDs were selected as study subjects, including 417 patients with Graves’ disease (GD), 250 patients with Hashimoto’s thyroiditis (HT) and 301 heal...

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Autores principales: Muhali, Fatuma-Said, Cai, Tian-tian, Zhu, Jiao-li, Qin, Qiu, Xu, Jian, He, Shuang-tao, Shi, Xiao-hong, Jiang, Wen-juan, Xiao, Ling, Li, Dan-Feng, Zhang, Jin-an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065265/
https://www.ncbi.nlm.nih.gov/pubmed/24646814
http://dx.doi.org/10.1534/g3.114.010926
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author Muhali, Fatuma-Said
Cai, Tian-tian
Zhu, Jiao-li
Qin, Qiu
Xu, Jian
He, Shuang-tao
Shi, Xiao-hong
Jiang, Wen-juan
Xiao, Ling
Li, Dan-Feng
Zhang, Jin-an
author_facet Muhali, Fatuma-Said
Cai, Tian-tian
Zhu, Jiao-li
Qin, Qiu
Xu, Jian
He, Shuang-tao
Shi, Xiao-hong
Jiang, Wen-juan
Xiao, Ling
Li, Dan-Feng
Zhang, Jin-an
author_sort Muhali, Fatuma-Said
collection PubMed
description To investigate the association of CLEC16A gene polymorphisms and autoimmune thyroid diseases (AITDs). Six hundred sixty seven Han Chinese patients with AITDs were selected as study subjects, including 417 patients with Graves’ disease (GD), 250 patients with Hashimoto’s thyroiditis (HT) and 301 healthy control patients. Polymerase chain reaction-restriction fragment length polymorphism (RFLP) and the mass spectrometry technique were used to genotype five CLEC16A single-nucleotide polymorphisms (SNPs) (rs12708716, rs12917716, rs12931878, rs2903692, and rs6498169). Higher frequency of G allele of rs6498169 CLEC16A gene in AITDs patients [P = 0.029, odds ratio (OR) 1.29 and 95% confidence interval 1.022−1.505] was observed. In addition an association between rs6498169 and HT was observed with statistical significance (P = 0.018, OR 1.335, 95% confidence interval 1.051−1.696). Furthermore, the GG haplotype containing the major allele of (rs12708716 and rs6498169) was associated with an increased risk of HT (P = 0.0148, OR 1.344). When patients with HT and controls were compared, results from the dominant and recessive models showed that the genotype frequency of rs6498169 were at borderline levels (P = 0.054 and P = 0.05), and the other four SNPs of CLEC16A gene showed no significant association with AITDs. Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs.
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spelling pubmed-40652652014-06-23 Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases Muhali, Fatuma-Said Cai, Tian-tian Zhu, Jiao-li Qin, Qiu Xu, Jian He, Shuang-tao Shi, Xiao-hong Jiang, Wen-juan Xiao, Ling Li, Dan-Feng Zhang, Jin-an G3 (Bethesda) Genetics of Immunity To investigate the association of CLEC16A gene polymorphisms and autoimmune thyroid diseases (AITDs). Six hundred sixty seven Han Chinese patients with AITDs were selected as study subjects, including 417 patients with Graves’ disease (GD), 250 patients with Hashimoto’s thyroiditis (HT) and 301 healthy control patients. Polymerase chain reaction-restriction fragment length polymorphism (RFLP) and the mass spectrometry technique were used to genotype five CLEC16A single-nucleotide polymorphisms (SNPs) (rs12708716, rs12917716, rs12931878, rs2903692, and rs6498169). Higher frequency of G allele of rs6498169 CLEC16A gene in AITDs patients [P = 0.029, odds ratio (OR) 1.29 and 95% confidence interval 1.022−1.505] was observed. In addition an association between rs6498169 and HT was observed with statistical significance (P = 0.018, OR 1.335, 95% confidence interval 1.051−1.696). Furthermore, the GG haplotype containing the major allele of (rs12708716 and rs6498169) was associated with an increased risk of HT (P = 0.0148, OR 1.344). When patients with HT and controls were compared, results from the dominant and recessive models showed that the genotype frequency of rs6498169 were at borderline levels (P = 0.054 and P = 0.05), and the other four SNPs of CLEC16A gene showed no significant association with AITDs. Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs. Genetics Society of America 2014-03-18 /pmc/articles/PMC4065265/ /pubmed/24646814 http://dx.doi.org/10.1534/g3.114.010926 Text en Copyright © 2014 Muhali et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Genetics of Immunity
Muhali, Fatuma-Said
Cai, Tian-tian
Zhu, Jiao-li
Qin, Qiu
Xu, Jian
He, Shuang-tao
Shi, Xiao-hong
Jiang, Wen-juan
Xiao, Ling
Li, Dan-Feng
Zhang, Jin-an
Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
title Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
title_full Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
title_fullStr Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
title_full_unstemmed Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
title_short Polymorphisms of CLEC16A Region and Autoimmune Thyroid Diseases
title_sort polymorphisms of clec16a region and autoimmune thyroid diseases
topic Genetics of Immunity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065265/
https://www.ncbi.nlm.nih.gov/pubmed/24646814
http://dx.doi.org/10.1534/g3.114.010926
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