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Biomarkers and chemopreventives in oral carcinogenesis and its prevention

Squamous cell carcinoma is the predominant type of oral malignancy and is a result of oral carcinogenesis. Oral carcinogenesis is a mutifactorial and complex process related to the sequential occurrence of alterations in genetic structures, promoting inhibitory or excitatory effects of the tumor onc...

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Detalles Bibliográficos
Autores principales: Shah, Sonalee, Kaur, Manpreet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065451/
https://www.ncbi.nlm.nih.gov/pubmed/24959040
http://dx.doi.org/10.4103/0973-029X.131914
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author Shah, Sonalee
Kaur, Manpreet
author_facet Shah, Sonalee
Kaur, Manpreet
author_sort Shah, Sonalee
collection PubMed
description Squamous cell carcinoma is the predominant type of oral malignancy and is a result of oral carcinogenesis. Oral carcinogenesis is a mutifactorial and complex process related to the sequential occurrence of alterations in genetic structures, promoting inhibitory or excitatory effects of the tumor oncogenes and gene suppressors, compromising the histophysiology of the division, differentiation and cell death; and therefore, methods to prevent, detect, or treat it in the best way is constantly being searched for. Biomarkers reveal the genetic and molecular changes related to early, intermediate and late endpoints in the process of oral carcinogenesis. Thereby, they are likely to not only refine our ability to predict the biologic course of oral cancer and distinguish individuals at high and/or low risk of oral cancer development; but, also they will also reveal the genetic and molecular changes related to various endpoints of oral carcinogenesis. Chemopreventives are chemicals of natural or synthetic origin, which reduce the incidence of fatal diseases such as cancer before clinical symptoms occur. Chemopreventives are agents whose curative capacity is defined with help of biomarkers, as the later determine the effectiveness and safety of chemopreventives.
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spelling pubmed-40654512014-06-23 Biomarkers and chemopreventives in oral carcinogenesis and its prevention Shah, Sonalee Kaur, Manpreet J Oral Maxillofac Pathol Review Article Squamous cell carcinoma is the predominant type of oral malignancy and is a result of oral carcinogenesis. Oral carcinogenesis is a mutifactorial and complex process related to the sequential occurrence of alterations in genetic structures, promoting inhibitory or excitatory effects of the tumor oncogenes and gene suppressors, compromising the histophysiology of the division, differentiation and cell death; and therefore, methods to prevent, detect, or treat it in the best way is constantly being searched for. Biomarkers reveal the genetic and molecular changes related to early, intermediate and late endpoints in the process of oral carcinogenesis. Thereby, they are likely to not only refine our ability to predict the biologic course of oral cancer and distinguish individuals at high and/or low risk of oral cancer development; but, also they will also reveal the genetic and molecular changes related to various endpoints of oral carcinogenesis. Chemopreventives are chemicals of natural or synthetic origin, which reduce the incidence of fatal diseases such as cancer before clinical symptoms occur. Chemopreventives are agents whose curative capacity is defined with help of biomarkers, as the later determine the effectiveness and safety of chemopreventives. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4065451/ /pubmed/24959040 http://dx.doi.org/10.4103/0973-029X.131914 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shah, Sonalee
Kaur, Manpreet
Biomarkers and chemopreventives in oral carcinogenesis and its prevention
title Biomarkers and chemopreventives in oral carcinogenesis and its prevention
title_full Biomarkers and chemopreventives in oral carcinogenesis and its prevention
title_fullStr Biomarkers and chemopreventives in oral carcinogenesis and its prevention
title_full_unstemmed Biomarkers and chemopreventives in oral carcinogenesis and its prevention
title_short Biomarkers and chemopreventives in oral carcinogenesis and its prevention
title_sort biomarkers and chemopreventives in oral carcinogenesis and its prevention
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065451/
https://www.ncbi.nlm.nih.gov/pubmed/24959040
http://dx.doi.org/10.4103/0973-029X.131914
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