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Efficient design of meganucleases using a machine learning approach

BACKGROUND: Meganucleases are important tools for genome engineering, providing an efficient way to generate DNA double-strand breaks at specific loci of interest. Numerous experimental efforts, ranging from in vivo selection to in silico modeling, have been made to re-engineer meganucleases to targ...

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Detalles Bibliográficos
Autores principales:	Zaslavskiy, Mikhail, Bertonati, Claudia, Duchateau, Philippe, Duclert, Aymeric, Silva, George H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065607/ https://www.ncbi.nlm.nih.gov/pubmed/24934562 http://dx.doi.org/10.1186/1471-2105-15-191

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