Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-Ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder

We synthesized twenty thiazolidin-4-one derivatives, which were then characterized by standard chromatographic and spectroscopic methods. From the in vitro glucose uptake assay, two compounds behaved as insulin sensitizers, where they enhanced glucose uptake in isolated rat diaphragm. In high-carboh...

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Detalles Bibliográficos
Autores principales: Gowdra, Vasantharaju S., Mudgal, Jayesh, Bansal, Punit, Nayak, Pawan G., Manohara Reddy, Seethappa A., Shenoy, Gautham G., Valiathan, Manna, Chamallamudi, Mallikarjuna R., Nampurath, Gopalan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065710/
https://www.ncbi.nlm.nih.gov/pubmed/24995315
http://dx.doi.org/10.1155/2014/620434

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