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Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics

Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment re...

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Detalles Bibliográficos
Autores principales: Kim, Jong-Heon, Yun, Sung-Ho, Jang, Kwang-Ho, Park, Jaechan, Han, Hyung Soo, Rhee, Dongick, Suk, Kyoungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065824/
https://www.ncbi.nlm.nih.gov/pubmed/24963275
http://dx.doi.org/10.5607/en.2014.23.2.115
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author Kim, Jong-Heon
Yun, Sung-Ho
Jang, Kwang-Ho
Park, Jaechan
Han, Hyung Soo
Rhee, Dongick
Suk, Kyoungho
author_facet Kim, Jong-Heon
Yun, Sung-Ho
Jang, Kwang-Ho
Park, Jaechan
Han, Hyung Soo
Rhee, Dongick
Suk, Kyoungho
author_sort Kim, Jong-Heon
collection PubMed
description Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment requires careful consideration of several factors including its practicality, feasibility, and associated risks. Here, we review the protective effects-and the cellular mechanisms that underlie them-of delayed and prolonged local hypothermia in rodent and canine brain injury models. The data show that the protective effects of therapeutic hypothermia, which mainly result from the modulation of inflammatory glial dynamics, are limited. We argue that decompressive craniectomy can be used to overcome the limitations of local brain hypothermia without causing histological abnormalities or other detrimental effects to the cooled area. Therefore, delayed and prolonged local brain hypothermia at the site of craniectomy is a promising intervention that may prove effective in the clinical setting.
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spelling pubmed-40658242014-06-24 Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics Kim, Jong-Heon Yun, Sung-Ho Jang, Kwang-Ho Park, Jaechan Han, Hyung Soo Rhee, Dongick Suk, Kyoungho Exp Neurobiol Review Article Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment requires careful consideration of several factors including its practicality, feasibility, and associated risks. Here, we review the protective effects-and the cellular mechanisms that underlie them-of delayed and prolonged local hypothermia in rodent and canine brain injury models. The data show that the protective effects of therapeutic hypothermia, which mainly result from the modulation of inflammatory glial dynamics, are limited. We argue that decompressive craniectomy can be used to overcome the limitations of local brain hypothermia without causing histological abnormalities or other detrimental effects to the cooled area. Therefore, delayed and prolonged local brain hypothermia at the site of craniectomy is a promising intervention that may prove effective in the clinical setting. The Korean Society for Brain and Neural Science 2014-06 2014-06-13 /pmc/articles/PMC4065824/ /pubmed/24963275 http://dx.doi.org/10.5607/en.2014.23.2.115 Text en Copyright © Experimental Neurobiology 2014. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Jong-Heon
Yun, Sung-Ho
Jang, Kwang-Ho
Park, Jaechan
Han, Hyung Soo
Rhee, Dongick
Suk, Kyoungho
Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_full Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_fullStr Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_full_unstemmed Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_short Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_sort delayed and prolonged local brain hypothermia combined with decompressive craniectomy: a novel therapeutic strategy that modulates glial dynamics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065824/
https://www.ncbi.nlm.nih.gov/pubmed/24963275
http://dx.doi.org/10.5607/en.2014.23.2.115
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