Cargando…

Use of Genetically Altered Stem Cells for the Treatment of Huntington’s Disease

Transplantation of stem cells for the treatment of Huntington’s disease (HD) garnered much attention prior to the turn of the century. Several studies using mesenchymal stem cells (MSCs) have indicated that these cells have enormous therapeutic potential in HD and other disorders. Advantages of usin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crane, Andrew T., Rossignol, Julien, Dunbar, Gary L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066244/ https://www.ncbi.nlm.nih.gov/pubmed/24961705 http://dx.doi.org/10.3390/brainsci4010202

Ejemplares similares

Use of Genetically Modified Mesenchymal Stem Cells to Treat Neurodegenerative Diseases
por: Wyse, Robert D., et al.
Publicado: (2014)

Prion‐like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy
por: Srinageshwar, Bhairavi, et al.
Publicado: (2020)

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease
por: Al-Gharaibeh, Abeer, et al.
Publicado: (2017)

Role of Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Treating Neurodegenerative Diseases
por: Srinageshwar, Bhairavi, et al.
Publicado: (2016)

CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington’s Disease
por: Kolli, Nivya, et al.
Publicado: (2017)

Silencing of the Mutant Huntingtin Gene through CRISPR-Cas9 Improves the Mitochondrial Biomarkers in an In Vitro Model of Huntington’s Disease
por: Dunbar, Gary L., et al.
Publicado: (2019)

Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number
por: Rossignol, Julien, et al.
Publicado: (2015)

Genetically Engineered Mesenchymal Stem Cells as a Proposed Therapeutic for Huntington’s Disease
por: Olson, Scott D., et al.
Publicado: (2011)

Use of Polyamidoamine Dendrimers in Brain Diseases
por: Florendo, Maria, et al.
Publicado: (2018)

PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
por: Fana, Michael, et al.
Publicado: (2020)

Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells
por: Deng, Peter, et al.
Publicado: (2016)

Huntington's disease: the case for genetic modifiers
por: Gusella, James F, et al.
Publicado: (2009)

Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease
por: Gharaibeh, Abeer, et al.
Publicado: (2020)

Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6/2 mice: behavioral and neuropathological analysis
por: Fink, Kyle D, et al.
Publicado: (2013)

Induced Pluripotent Stem Cells in Huntington’s Disease Research: Progress and Opportunity
por: Tousley, Adelaide, et al.
Publicado: (2016)

Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington’s disease
por: Saha, Sudeepto, et al.
Publicado: (2022)

Current Therapeutic Strategies for Glioblastoma
por: Rossignol, Julien, et al.
Publicado: (2019)

New Avenues for the Treatment of Huntington’s Disease
por: Kim, Amy, et al.
Publicado: (2021)

Altered Cholesterol Homeostasis in Huntington’s Disease
por: Kacher, Radhia, et al.
Publicado: (2022)

Transplantation of mesenchymal stem cells overexpressing interleukin‐10 induces autophagy response and promotes neuroprotection in a rat model of TBI
por: Maiti, Panchanan, et al.
Publicado: (2019)

Mesenchymal Stem Cell Therapy for Huntington Disease: A Meta-Analysis
por: Liang, Xue-Song, et al.
Publicado: (2023)

Stem Cells for Huntington’s Disease (SC4HD): An International Consortium to Facilitate Stem Cell-Based Therapy for Huntington’s Disease
Publicado: (2021)

Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease
por: Naphade, Swati, et al.
Publicado: (2018)

Altered Fractional Anisotropy in Early Huntington's Disease
por: Singh, Silky, et al.
Publicado: (2013)

Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease
por: Cummings, Damian M, et al.
Publicado: (2010)

Irritability in Huntington’s Disease
por: Karagas, Nicholas E., et al.
Publicado: (2020)

Predictive genetic testing in Huntington's disease
por: Muthane, Uday
Publicado: (2011)

Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease
por: McCourt, Andrew C, et al.
Publicado: (2015)

Genetic mouse models of Huntington’s disease: focus on electrophysiological mechanisms
por: Cepeda, Carlos, et al.
Publicado: (2010)

The Neurodevelopmental Hypothesis of Huntington’s Disease
por: van der Plas, Ellen, et al.
Publicado: (2020)

Therapeutic Strategies in Huntington’s Disease: From Genetic Defect to Gene Therapy
por: Jurcau, Anamaria, et al.
Publicado: (2022)

Pharmacogenetics in the Treatment of Huntington’s Disease: Review and Future Perspectives
por: García-González, Xandra, et al.
Publicado: (2023)

Cell-based technologies for Huntington’s disease
por: Haddad, Mônica Santoro, et al.
Publicado: (2016)

Neural and mesenchymal stem cells in animal models of Huntington’s disease: past experiences and future challenges
por: Kerkis, Irina, et al.
Publicado: (2015)

Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies
por: Martinez, Bridget, et al.
Publicado: (2021)

Genetic Rat Models of Parkinson's Disease
por: Welchko, Ryan M., et al.
Publicado: (2012)

Huntington Disease in Asia
por: Xu, Miao, et al.
Publicado: (2015)

Altered lipid metabolism in Drosophila model of Huntington’s disease
por: Aditi, Kumari, et al.
Publicado: (2016)

Huntington’s disease skeletal muscle has altered T-tubules
por: Khan, Muhammad S., et al.
Publicado: (2021)

Therapeutic Strategies in Huntington's Disease
por: Kanazawa, Ichiro
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_7pc908trj6e8q4pcdfanm1q7u4