A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost nothing is known about events leading to this islet autoimmunity. Previous epidemiological and genetic data have associated viral infections and...

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Detalles Bibliográficos
Autores principales: Ferreira, Ricardo C., Guo, Hui, Coulson, Richard M.R., Smyth, Deborah J., Pekalski, Marcin L., Burren, Oliver S., Cutler, Antony J., Doecke, James D., Flint, Shaun, McKinney, Eoin F., Lyons, Paul A., Smith, Kenneth G.C., Achenbach, Peter, Beyerlein, Andreas, Dunger, David B., Clayton, David G., Wicker, Linda S., Todd, John A., Bonifacio, Ezio, Wallace, Chris, Ziegler, Anette-G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066333/
https://www.ncbi.nlm.nih.gov/pubmed/24561305
http://dx.doi.org/10.2337/db13-1777

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