Cargando…

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol (DAG), a lipid that has been linked to the development of hepatic insulin resistance through activation of protein kinase C (PKC). The expression of genes that encode MGAT enzymes is induced in the livers of i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hall, Angela M., Soufi, Nisreen, Chambers, Kari T., Chen, Zhouji, Schweitzer, George G., McCommis, Kyle S., Erion, Derek M., Graham, Mark J., Su, Xiong, Finck, Brian N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066334/ https://www.ncbi.nlm.nih.gov/pubmed/24595352 http://dx.doi.org/10.2337/db13-1502

Ejemplares similares

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans
por: Liss, Kim H. H., et al.
Publicado: (2018)

Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism
por: McCommis, Kyle S., et al.
Publicado: (2018)

The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease
por: McCommis, Kyle S., et al.
Publicado: (2023)

Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1
por: Lutkewitte, Andrew J., et al.
Publicado: (2021)

Glucose Transporter 8 (GLUT8) Mediates Fructose-induced de Novo Lipogenesis and Macrosteatosis
por: DeBosch, Brian J., et al.
Publicado: (2014)

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
por: McCommis, Kyle S., et al.
Publicado: (2016)

Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway
por: Petrie, James R., et al.
Publicado: (2012)

The monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells
por: McFie, Pamela J., et al.
Publicado: (2022)

Treating fatty liver disease by modulating mitochondrial pyruvate metabolism
por: Colca, Jerry R., et al.
Publicado: (2017)

Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations
por: Chambers, Kari T., et al.
Publicado: (2021)

Correction: Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway
por: Petrie, James R., et al.
Publicado: (2012)

Editorial: Diabetes and non-alcoholic fatty liver disease: points of physiological and mechanistic intersection and current co-therapeutic approaches
por: Giannoukakis, Nick, et al.
Publicado: (2023)

Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
por: Yu, Jung Hwan, et al.
Publicado: (2016)

Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis
por: Lee, Yoo Jeong, et al.
Publicado: (2017)

Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes
por: Hayashi, Yasuhiro, et al.
Publicado: (2014)

Transcriptional and biochemical responses of monoacylglycerol acyltransferase-mediated oil synthesis and associated senescence-like responses in Nicotiana benthamiana
por: Divi, Uday K., et al.
Publicado: (2014)

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization
por: Take, Kazumi, et al.
Publicado: (2016)

Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation
por: Fenyk, Stepan, et al.
Publicado: (2022)

Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets
por: Berdan, Charles A., et al.
Publicado: (2016)

Novel Cell-Based Assay to Investigate Monoacylglycerol Acyltransferase 2 Inhibitory Activity Using HIEC-6 Cell Line
por: Singh, Yeshvanthi, et al.
Publicado: (2021)

Two Faces of Pioglitazone: Sorting Out the Roles of its PPARγ Binding Versus Mitochondrial Pyruvate Carrier Inhibition Is Not So Simple
por: Yuan, Liyun, et al.
Publicado: (2021)

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
por: Hirvonen, Jussi, et al.
Publicado: (2011)

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening
por: Hegazy, Lamees, et al.
Publicado: (2022)

Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver
por: Ehara, Tatsuya, et al.
Publicado: (2012)

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide
por: Kamm, Dakota R., et al.
Publicado: (2021)

Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
por: Tong, Jenny, et al.
Publicado: (2010)

Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux
por: McCommis, Kyle S., et al.
Publicado: (2013)

Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells
por: Sankella, Shireesha, et al.
Publicado: (2016)

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
por: Kars, Marleen, et al.
Publicado: (2010)

Reduced first-phase insulin secretion increases postprandial lipidemia in subjects with impaired glucose tolerance
por: Gómez-Sámano, Miguel Ángel, et al.
Publicado: (2017)

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
por: Matveyenko, Aleksey V., et al.
Publicado: (2012)

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis
por: Gansemer, Erica R., et al.
Publicado: (2020)

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis
por: Gansemer, Erica R., et al.
Publicado: (2022)

Insulin resistance of protein anabolism accompanies that of glucose metabolism in lean, glucose-tolerant offspring of persons with type 2 diabetes
por: Burgos, Sergio A, et al.
Publicado: (2016)

Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo
por: Mukherjee, Sandip, et al.
Publicado: (2023)

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet
por: Gupte, Anisha A., et al.
Publicado: (2009)

Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures
por: Prystupa, Katsiaryna, et al.
Publicado: (2022)

m.3243A>G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive β-Cell Dysfunction
por: Lindroos, Markus M., et al.
Publicado: (2009)

Hepatic and Extrahepatic Insulin Clearance Are Differentially Regulated: Results From a Novel Model-Based Analysis of Intravenous Glucose Tolerance Data
por: Polidori, David C., et al.
Publicado: (2016)

Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression
por: Baek, Kyung-Wan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dv2jtva4uojog6oju6lk71jpaj