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B Cells: The Old New Players in Reproductive Immunology

Reproductive immunology research has long focused on T cell responses to paternal antigens and tolerance mechanisms supporting fetal well-being. The participation of B cells herein was not widely studied. Because of the fascinating immunological uniqueness of pregnancy, it is however to be expected...

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Autores principales: Fettke, Franziska, Schumacher, Anne, Costa, Serban-Dan, Zenclussen, Ana Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066365/
https://www.ncbi.nlm.nih.gov/pubmed/25002862
http://dx.doi.org/10.3389/fimmu.2014.00285
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author Fettke, Franziska
Schumacher, Anne
Costa, Serban-Dan
Zenclussen, Ana Claudia
author_facet Fettke, Franziska
Schumacher, Anne
Costa, Serban-Dan
Zenclussen, Ana Claudia
author_sort Fettke, Franziska
collection PubMed
description Reproductive immunology research has long focused on T cell responses to paternal antigens and tolerance mechanisms supporting fetal well-being. The participation of B cells herein was not widely studied. Because of the fascinating immunological uniqueness of pregnancy, it is however to be expected that such pleiotropic cells play a considerable role. In fact, on the one hand B cells contribute toward pregnancy tolerance by secreting the immunomodulatory cytokine IL-10 but on the other hand can seriously harm pregnancy because of their capacity of producing autoantibodies. As for protective B cells, new evidences in mouse models arise suggesting that IL-10 producing B cells, the so-called B10 cells, help in maintaining tolerance toward semi-allogenic fetal antigens. They may be also important to fight danger signals at the fetal-maternal interface as, e.g., in the case of infections with the aim to restore the disrupted fetal tolerance. In human pregnancies, IL-10 producing B cells increase with pregnancy onset but not in the case of spontaneous abortions. In vitro, they are able to suppress TNF-α production by T cells from pregnant individuals. Their generation and functionality will be discussed throughout this review article. B cells can be deleterious to pregnancy as well. Aberrant B cell compartment is associated with obstetric pathologies. In particular, the capacity of B2 cells to produce specific autoantibodies or of B-1a B cells to secrete natural autoantibodies that can turn autoreactive will be discussed herein.
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spelling pubmed-40663652014-07-07 B Cells: The Old New Players in Reproductive Immunology Fettke, Franziska Schumacher, Anne Costa, Serban-Dan Zenclussen, Ana Claudia Front Immunol Immunology Reproductive immunology research has long focused on T cell responses to paternal antigens and tolerance mechanisms supporting fetal well-being. The participation of B cells herein was not widely studied. Because of the fascinating immunological uniqueness of pregnancy, it is however to be expected that such pleiotropic cells play a considerable role. In fact, on the one hand B cells contribute toward pregnancy tolerance by secreting the immunomodulatory cytokine IL-10 but on the other hand can seriously harm pregnancy because of their capacity of producing autoantibodies. As for protective B cells, new evidences in mouse models arise suggesting that IL-10 producing B cells, the so-called B10 cells, help in maintaining tolerance toward semi-allogenic fetal antigens. They may be also important to fight danger signals at the fetal-maternal interface as, e.g., in the case of infections with the aim to restore the disrupted fetal tolerance. In human pregnancies, IL-10 producing B cells increase with pregnancy onset but not in the case of spontaneous abortions. In vitro, they are able to suppress TNF-α production by T cells from pregnant individuals. Their generation and functionality will be discussed throughout this review article. B cells can be deleterious to pregnancy as well. Aberrant B cell compartment is associated with obstetric pathologies. In particular, the capacity of B2 cells to produce specific autoantibodies or of B-1a B cells to secrete natural autoantibodies that can turn autoreactive will be discussed herein. Frontiers Media S.A. 2014-06-23 /pmc/articles/PMC4066365/ /pubmed/25002862 http://dx.doi.org/10.3389/fimmu.2014.00285 Text en Copyright © 2014 Fettke, Schumacher, Costa and Zenclussen. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Fettke, Franziska
Schumacher, Anne
Costa, Serban-Dan
Zenclussen, Ana Claudia
B Cells: The Old New Players in Reproductive Immunology
title B Cells: The Old New Players in Reproductive Immunology
title_full B Cells: The Old New Players in Reproductive Immunology
title_fullStr B Cells: The Old New Players in Reproductive Immunology
title_full_unstemmed B Cells: The Old New Players in Reproductive Immunology
title_short B Cells: The Old New Players in Reproductive Immunology
title_sort b cells: the old new players in reproductive immunology
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066365/
https://www.ncbi.nlm.nih.gov/pubmed/25002862
http://dx.doi.org/10.3389/fimmu.2014.00285
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