Unlocking epigenetic codes in neurogenesis

During embryonic and adult neurogenesis, neuronal stem cells follow a highly conserved path of differentiation to give rise to functional neurons at various developmental stages. Epigenetic regulation—including DNA modifications, histone modifications, and noncoding regulatory RNAs, such as microRNA...

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Detalles Bibliográficos
Autores principales: Yao, Bing, Jin, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066397/
https://www.ncbi.nlm.nih.gov/pubmed/24939932
http://dx.doi.org/10.1101/gad.241547.114
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author Yao, Bing
Jin, Peng
author_facet Yao, Bing
Jin, Peng
author_sort Yao, Bing
collection PubMed
description During embryonic and adult neurogenesis, neuronal stem cells follow a highly conserved path of differentiation to give rise to functional neurons at various developmental stages. Epigenetic regulation—including DNA modifications, histone modifications, and noncoding regulatory RNAs, such as microRNA (miRNA) and long noncoding RNA (lncRNA)—plays a pivotal role in embryonic and adult neurogenesis. Here we review the latest in our understanding of the epigenetic regulation in neurogenesis, with a particular focus on newly identified cytosine modifications and their dynamics, along with our perspective for future studies.
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spelling pubmed-40663972014-12-15 Unlocking epigenetic codes in neurogenesis Yao, Bing Jin, Peng Genes Dev Review During embryonic and adult neurogenesis, neuronal stem cells follow a highly conserved path of differentiation to give rise to functional neurons at various developmental stages. Epigenetic regulation—including DNA modifications, histone modifications, and noncoding regulatory RNAs, such as microRNA (miRNA) and long noncoding RNA (lncRNA)—plays a pivotal role in embryonic and adult neurogenesis. Here we review the latest in our understanding of the epigenetic regulation in neurogenesis, with a particular focus on newly identified cytosine modifications and their dynamics, along with our perspective for future studies. Cold Spring Harbor Laboratory Press 2014-06-15 /pmc/articles/PMC4066397/ /pubmed/24939932 http://dx.doi.org/10.1101/gad.241547.114 Text en © 2014 Yao and Jin; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Yao, Bing
Jin, Peng
Unlocking epigenetic codes in neurogenesis
title Unlocking epigenetic codes in neurogenesis
title_full Unlocking epigenetic codes in neurogenesis
title_fullStr Unlocking epigenetic codes in neurogenesis
title_full_unstemmed Unlocking epigenetic codes in neurogenesis
title_short Unlocking epigenetic codes in neurogenesis
title_sort unlocking epigenetic codes in neurogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066397/
https://www.ncbi.nlm.nih.gov/pubmed/24939932
http://dx.doi.org/10.1101/gad.241547.114
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