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How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes
The duplication of transcription regulators can elicit major regulatory network rearrangements over evolutionary timescales. However, few examples of duplications resulting in gene network expansions are understood in molecular detail. Here we show that four Candida albicans transcription regulators...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066398/ https://www.ncbi.nlm.nih.gov/pubmed/24874988 http://dx.doi.org/10.1101/gad.242271.114 |
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author | Pérez, J. Christian Fordyce, Polly M. Lohse, Matthew B. Hanson-Smith, Victor DeRisi, Joseph L. Johnson, Alexander D. |
author_facet | Pérez, J. Christian Fordyce, Polly M. Lohse, Matthew B. Hanson-Smith, Victor DeRisi, Joseph L. Johnson, Alexander D. |
author_sort | Pérez, J. Christian |
collection | PubMed |
description | The duplication of transcription regulators can elicit major regulatory network rearrangements over evolutionary timescales. However, few examples of duplications resulting in gene network expansions are understood in molecular detail. Here we show that four Candida albicans transcription regulators that arose by successive duplications have differentiated from one another by acquiring different intrinsic DNA-binding specificities, different preferences for half-site spacing, and different associations with cofactors. The combination of these three mechanisms resulted in each of the four regulators controlling a distinct set of target genes, which likely contributed to the adaption of this fungus to its human host. Our results illustrate how successive duplications and diversification of an ancestral transcription regulator can underlie major changes in an organism’s regulatory circuitry. |
format | Online Article Text |
id | pubmed-4066398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40663982014-12-15 How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes Pérez, J. Christian Fordyce, Polly M. Lohse, Matthew B. Hanson-Smith, Victor DeRisi, Joseph L. Johnson, Alexander D. Genes Dev Research Communication The duplication of transcription regulators can elicit major regulatory network rearrangements over evolutionary timescales. However, few examples of duplications resulting in gene network expansions are understood in molecular detail. Here we show that four Candida albicans transcription regulators that arose by successive duplications have differentiated from one another by acquiring different intrinsic DNA-binding specificities, different preferences for half-site spacing, and different associations with cofactors. The combination of these three mechanisms resulted in each of the four regulators controlling a distinct set of target genes, which likely contributed to the adaption of this fungus to its human host. Our results illustrate how successive duplications and diversification of an ancestral transcription regulator can underlie major changes in an organism’s regulatory circuitry. Cold Spring Harbor Laboratory Press 2014-06-15 /pmc/articles/PMC4066398/ /pubmed/24874988 http://dx.doi.org/10.1101/gad.242271.114 Text en © 2014 Pérez et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Communication Pérez, J. Christian Fordyce, Polly M. Lohse, Matthew B. Hanson-Smith, Victor DeRisi, Joseph L. Johnson, Alexander D. How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
title | How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
title_full | How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
title_fullStr | How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
title_full_unstemmed | How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
title_short | How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
title_sort | how duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes |
topic | Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066398/ https://www.ncbi.nlm.nih.gov/pubmed/24874988 http://dx.doi.org/10.1101/gad.242271.114 |
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